ArticleMolecular endocrinology (Baltimore, Md.)2013
RIG-I-like receptors mediate innate antiviral response in mouse testis.
Article in Molecular endocrinology (Baltimore, Md.), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 41 citations in OpenAlex.
- Targeting SHP-1 to alleviate testicular inflammation and apoptosis in a Poly(I:C)-induced orchitis model.European journal of medical research · 2025Article
- SARS-CoV-2 exploits steroidogenic machinery, triggers lipid metabolism for viral replication and induces immune response in Leydig cells of K18-hACE2 mice.Frontiers in cellular and infection microbiology · 2025Article
- Innate Antiviral Defense of the Male Reproductive System.Advances in experimental medicine and biology · 2025Review
- A multi-omics analysis of viral nucleic acid poly(I:C) responses to mammalian testicular stimulation.Stress biology · 2024Article
- Viral tropism for the testis and sexual transmission.Frontiers in immunology · 2022Review
- Cytosolic delivery of the immunological adjuvant Poly I:C and cytotoxic drug crystalsActa pharmaceutica Sinica. B · 2021Article
- Immunologic Environment of the Testis.Advances in experimental medicine and biology · 2021Article
- OCT4 Represses Inflammation and Cell Injury During Orchitis by Regulating CIP2A Expression.Frontiers in cell and developmental biology · 2021Article
- Roles of Sialic Acid, AXL, and MER Receptor Tyrosine Kinases in Mumps Virus Infection of Mouse Sertoli and Leydig Cells.Frontiers in microbiology · 2020Article
- CircRNA-9119 suppresses poly I:C induced inflammation in Leydig and Sertoli cells via TLR3 and RIG-I signal pathways.Molecular medicine (Cambridge, Mass.) · 2019Article
- Region-specific innate antiviral responses of the human epididymis.Molecular and cellular endocrinology · 2018Article
- Zika virus causes testicular atrophy.Science advances · 2017Article
- Mouse Testicular Cell Type-Specific Antiviral Response against Mumps Virus Replication.Frontiers in immunology · 2017Article
- Mumps virus-induced innate immune responses in mouse Sertoli and Leydig cells.Scientific reports · 2016Article
- Roles of Toll-like receptors 2 and 4 in mediating experimental autoimmune orchitis induction in mice.Biology of reproduction · 2015Article
- Testicular defense systems: immune privilege and innate immunity.Cellular & molecular immunology · 2014Review
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The testis is an immune privileged organ in which the tissue-specific cells have adopted effective innate immune functions against microbial pathogens. Toll-like receptors (TLRs) mediate innate immune response in the testis. The current study demonstrates that melanoma differentiation-associated protein 5 (MDA5) and retinoic acid-inducible gene I (RIG-I) initiate the testicular innate antiviral response. Both MDA5 and RIG-I are expressed in Leydig cells, and MDA5 is also expressed in spermatids. Polyinosinic-polycytidylic acid [poly(I:C)], a common agonist of MDA5 and RIG-I, significantly induces the expression of type I interferons (IFN-α/β) and antiviral proteins, including IFN-stimulated gene 15, 2'5'-oligoadenylate synthetase 1, and Mx GTPase 1, in primary TLR3-deficient (TLR3(-/-)) Leydig and germ cells. Moreover, major proinflammatory cytokines, including TNF-α and IL-6, are significantly up-regulated by poly(I:C) in these testicular cells. The poly(I:C)-induced innate antiviral response in the testicular cells is significantly reduced by knockdown of individual MDA5 and RIG-I using specific small interfering RNA. We also provide evidence that local injection of poly(I:C) induces antiviral response in the testis of TLR3(-/-) mice. These data provide novel insights into the mechanisms underlying testicular antiviral response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.