ArticleAmerican journal of epidemiology2013
Association of the FTO obesity risk variant rs8050136 with percentage of energy intake from fat in multiple racial/ethnic populations: the PAGE study.
Article in American journal of epidemiology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 4 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 4 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Genetic Variants in the Fat Mass and Obesity-Associated Gene and Risk of Obesity/Overweight in Children and Adolescents: A Systematic Review and Meta-Analysis.Endocrinology, diabetes & metabolism · 2024Pooled it
- In the context of the triple burden of malnutrition: A systematic review of gene-diet interactions and nutritional status.Critical reviews in food science and nutrition · 2024Pooled it
- New insight into human sweet taste: a genome-wide association study of the perception and intake of sweet substances.The American journal of clinical nutrition · 2019Pooled it
- Associations between Single Nucleotide Polymorphisms and Total Energy, Carbohydrate, and Fat Intakes: A Systematic Review.Advances in nutrition (Bethesda, Md.) · 2018Pooled it
- An obesogenic FTO allele causes accelerated development, growth and insulin resistance in human skeletal muscle cells.Nature communications · 2025Article
- Research progress on the mechanistic impact of single-nucleotide polymorphisms and dietary pattern interactions on overweight and obesity in Chinese adults: a narrative review.Frontiers in nutrition · 2025Review
- Association of anthropometric indices with rs9939609Frontiers in nutrition · 2025Article
- Review
- Article
- Article
- Interactions of anthropometric indices, rs9939609 FTO gene polymorphism and breast cancer: A case-control study.Journal of cellular and molecular medicine · 2021Article
- Effects of Gene-Environment Interaction on Obesity among Chinese Adults Born in the Early 1960s.Genes · 2021Article
- Common genetic variants associated with obesity in an African-American and Hispanic/Latino population.PloS one · 2021Article
- The Impact ofNutrients · 2020Article
- Genome-wide association study of dietary intake in the UK biobank study and its associations with schizophrenia and other traits.Translational psychiatry · 2020Article
- Differential effects on neurodevelopment of FTO variants in obesity and bipolar disorder suggested by in silico prediction of functional impact: An analysis in Mexican population.Brain and behavior · 2019Article
- Nutritional Genomics and Direct-to-Consumer Genetic Testing: An Overview.Advances in nutrition (Bethesda, Md.) · 2018Review
- What Twin Studies Tell Us About Brain Responses to Food Cues.Current obesity reports · 2017Review
- The role of early life growth development, the FTO gene and exclusive breastfeeding on child BMI trajectories.International journal of epidemiology · 2017Article
- Mediterranean Dietary Pattern Adherence Modify the Association between FTO Genetic Variations and Obesity Phenotypes.Nutrients · 2017Article
Corrections and comments
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Authors and funding
23 authors at 8 institutions in 1 country.
Funding
Abstract
Common obesity risk variants have been associated with macronutrient intake; however, these associations' generalizability across populations has not been demonstrated. We investigated the associations between 6 obesity risk variants in (or near) the NEGR1, TMEM18, BDNF, FTO, MC4R, and KCTD15 genes and macronutrient intake (carbohydrate, protein, ethanol, and fat) in 3 Population Architecture using Genomics and Epidemiology (PAGE) studies: the Multiethnic Cohort Study (1993-2006) (n = 19,529), the Atherosclerosis Risk in Communities Study (1987-1989) (n = 11,114), and the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) Study, which accesses data from the Third National Health and Nutrition Examination Survey (1991-1994) (n = 6,347). We used linear regression, with adjustment for age, sex, and ethnicity, to estimate the associations between obesity risk genotypes and macronutrient intake. A fixed-effects meta-analysis model showed that the FTO rs8050136 A allele (n = 36,973) was positively associated with percentage of calories derived from fat (βmeta = 0.2244 (standard error, 0.0548); P = 4 × 10(-5)) and inversely associated with percentage of calories derived from carbohydrate (βmeta = -0.2796 (standard error, 0.0709); P = 8 × 10(-5)). In the Multiethnic Cohort Study, percentage of calories from fat assessed at baseline was a partial mediator of the rs8050136 effect on body mass index (weight (kg)/height (m)(2)) obtained at 10 years of follow-up (mediation of effect = 0.0823 kg/m(2), 95% confidence interval: 0.0559, 0.1128). Our data provide additional evidence that the association of FTO with obesity is partially mediated by dietary intake.
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