ArticleMolecular & cellular proteomics : MCP2013
Sucrose-induced receptor kinase SIRK1 regulates a plasma membrane aquaporin in Arabidopsis.
Article in Molecular & cellular proteomics : MCP, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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48 citing papers in PubMed, 99 citations in OpenAlex.
- Mevalonate kinase represses anthocyanin biosynthesis via sucrose transporters and gibberellin synthesis pathways in arabidopsis.Plant cell reports · 2026Article
- Transcriptional and post-translational regulation of aquaporins in plants.Stress biology · 2026Review
- MEVALONATE KINASE represses anthocyanin biosynthesis via sucrose transporters and gibberellin synthesis pathways in Arabidopsis.Research square · 2025Article
- Post-translational modification acts as a digital like switch influencing AtPIP2;1 water and cation permeability.Scientific reports · 2025Article
- Abscisic acid enhances DNA damage response through the nuclear shuttling of clathrin light chain 2 in plant cells.Science advances · 2025Article
- Subfamily C7 Raf-like kinases MRK1, RAF26, and RAF39 regulate immune homeostasis and stomatal opening in Arabidopsis thaliana.The New phytologist · 2024Article
- Exploring aquaporin functions during changes in leaf water potential.Frontiers in plant science · 2023Review
- The Role of Aquaporins in Plant Growth under Conditions of Oxygen Deficiency.International journal of molecular sciences · 2022Review
- Critical roles of the activation of ethylene pathway genes mediated by DNA demethylation in Arabidopsis hyperhydricity.The plant genome · 2022Article
- Histidine kinase inhibitors impair shoot regeneration inFrontiers in plant science · 2022Article
- Sucrose targets clathrin-mediated endocytosis kinetics supporting cell elongation inFrontiers in plant science · 2022Article
- Regulatory Modules of Metabolites and Protein Phosphorylation in Arabidopsis Genotypes With Altered Sucrose Allocation.Frontiers in plant science · 2022Article
- Proton and calcium pumping P-type ATPases and their regulation of plant responses to the environment.Plant physiology · 2021Review
- Hormonal and environmental signaling pathways target membrane water transport.Plant physiology · 2021Review
- Low ABA concentration promotes root growth and hydrotropism through relief of ABA INSENSITIVE 1-mediated inhibition of plasma membrane HScience advances · 2021Article
- Phosphoproteomic Profiling Reveals Early Salt-Responsive Mechanisms in Two Foxtail Millet Cultivars.Frontiers in plant science · 2021Article
- Computational Phosphorylation Network Reconstruction: An Update on Methods and Resources.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Phosphoproteomics Profiling of Receptor Kinase Mutants.Methods in molecular biology (Clifton, N.J.) · 2021Article
- Plasma membrane aquaporins interact with the endoplasmic reticulum resident VAP27 proteins at ER-PM contact sites and endocytic structures.The New phytologist · 2020Article
- Global Quantitative Proteomics Studies Revealed Tissue-Preferential Expression and Phosphorylation of Regulatory Proteins inInternational journal of molecular sciences · 2020Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The transmembrane receptor kinase family is the largest protein kinase family in Arabidopsis, and it contains the highest fraction of proteins with yet uncharacterized functions. Here, we present functions of SIRK1, a receptor kinase that was previously identified with rapid transient phosphorylation after sucrose resupply to sucrose-starved seedlings. SIRK1 was found to be an active kinase with increasing activity in the presence of an external sucrose supply. In sirk1 T-DNA insertional mutants, the sucrose-induced phosphorylation patterns of several membrane proteins were strongly reduced; in particular, pore-gating phosphorylation sites in aquaporins were affected. SIRK1-GFP fusions were found to directly interact with aquaporins in affinity pull-down experiments on microsomal membrane vesicles. Furthermore, protoplast swelling assays of sirk1 mutants and SIRK1-GFP expressing lines confirmed a direct functional interaction of receptor kinase SIRK1 and aquaporins as substrates for phosphorylation. A lack of SIRK1 expression resulted in the failure of mutant protoplasts to control water channel activity upon changes in external sucrose concentrations. We propose that SIRK1 is involved in the regulation of sucrose-specific osmotic responses through direct interaction with and activation of an aquaporin via phosphorylation and that the duration of this response is controlled by phosphorylation-dependent receptor internalization.
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