ArticleParasitology research2013
Development of a facile system for mass production of Brugia malayi in a small-space laboratory.
Article in Parasitology research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 12 citations in OpenAlex.
- Lipid biomarker profiling of adult3 Biotech · 2022Article
- A Component-Resolved Therapeutic Vaccine for Cockroach Allergy Made of Per a 9 and Transforming Growth Factor-β Homologue, an Immunosuppressive Protein ofFrontiers in immunology · 2021Article
- Immune responses of Aedes togoi, Anopheles paraliae and Anopheles lesteri against nocturnally subperiodic Brugia malayi microfilariae during migration from the midgut to the site of development.Parasites & vectors · 2018Article
- Lessons from the genomes and transcriptomes of filarial nematodes.Molecular and biochemical parasitology · 2017Review
- An effective method for the identification and separation of Anopheles minimus, the primary malaria vector in Thailand, and its sister species Anopheles harrisoni, with a comparison of their mating behaviors.Parasites & vectors · 2017Article
- Exsheathment and midgut invasion of nocturnally subperiodic Brugia malayi microfilariae in a refractory vector, Aedes aegypti (Thailand strain).Parasitology research · 2014Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brugia malayi is one of the important lymphatic filarial nematodes that cause elephantiasis and disability in humans in the Asian region. Mass production at any stage of this nematode in both small laboratory animal hosts and mosquito vectors is still necessary in order to continue various research aspects. This study elucidated on the use of nonblood feeding or the autogenous Ochlerotatus togoi (Thailand strain) and male Mongolian jird (Meriones unguiculatus) system. This has brought about a low-cost and highly-effective procedure for the mass production of blood containing microfilariae, infective (L3) larvae, and adults of B. malayi under nonanimal-blood-feeding insectary and small-space animal-house conditions. The highly-infective rates (human-heparinized blood, 86.67-93.33; swine-heparinized blood, 83.33-96.67; bovine-heparinized blood, 76.67-80; chicken-heparinized blood, 73.33-76.67) and parasite loads (human-heparinized blood, 10.58-12.36; swine-heparinized blood, 8.40-10.38; bovine-heparinized blood, 9.75-9.91; chicken-heparinized blood, 3.41-4.65) of autogenous O. togoi to B. malayi and high numbers of adults recovered from ten B. malayi-infected male jirds (total = 327, 16-52) are good supportive evidence. In addition, all special techniques required for succeeding in the establishment of a facile system regarding these matters are detailed.
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