Evidence map›Paper›PMID 23820600›Full record

ArticleMenopause (New York, N.Y.)2014

Increased hot flash severity and related interference in perimenopausal human immunodeficiency virus-infected women.

Sara E Looby, Jan Shifren, Inge Corless, Alison Rope, Maria C Pedersen, Hadine Joffe, Steven Grinspoon

Abstract read
In one paragraph

Article in Menopause (New York, N.Y.), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

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  9. A practical clinical guide to counselling on and managing contraception, pre-conception planning, and menopause for women living with HIV.Journal of the Association of Medical Microbiology and Infectious Disease Canada = Journal officiel de l'Association pour la microbiologie medicale et l'infectiologie Canada · 2021
    Article
  10. Article
  11. Review of menopausal palpitations measures.Women's midlife health · 2021
    Review
  12. Article
  13. Article
  14. Article
  15. Observational
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sara E LoobyFrom the 1Massachusetts General Hospital Program in Nutritional Metabolism, Boston, MA; 2Massachusetts General Hospital Vincent Obstetrics and Gynecology, Boston, MA; 3Massachusetts General Hospital Institute of Health Professions, Charlestown, MA; and 4Massachusetts General Hospital Center for Women's Mental Health, Boston, MA.
Jan Shifren
Inge Corless
Alison Rope
Maria C Pedersen
Hadine Joffe
Steven Grinspoon

Funding

ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MARTIN TORRIANI · 1994 to 2026
$31.6M
Harvard Clinical and Translational Science Center (UL1)UL1TR000170 · NCATS · HARVARD MEDICAL SCHOOL · PI NADLER, LEE MARSHALL · 2012 to 2013
$31.4M
Metabolic and Psychosocial Changes Associated with Menopause among Women with HIVK23NR011833 · NINR · MASSACHUSETTS GENERAL HOSPITAL · PI LOOBY, SARA ELIZABETH DOLAN · 2010 to 2012
$403k
NCATS NIH HHS 8UL1TR000170-05NCATS NIH HHS UL1 TR000170NIDDK NIH HHS P30 DK040561NIDDK NIH HHS P30-DK040561NINR NIH HHS K23 NR011833NINR NIH HHS NIH K23 NR011833-01A1
6 · The paper itself

Abstract

objectiveAs women with human immunodeficiency virus (HIV) are living longer, more are entering perimenopause. Prior studies suggest that HIV-infected women are more likely to have hot flashes than non-HIV-infected women. However, little is known regarding hot flash severity and hot flash-related interference with daily function, mood, and quality of life in this population.

methodsPerimenopausal HIV-infected and non-HIV-infected women matched by age, race, and menstrual patterns completed the Menopause Rating Scale (to assess hot flash severity) and the Hot Flash Related Daily Interference Scale (HFRDIS). Menopause Rating Scale and HFRDIS scores and subscores were compared between the groups.

resultsThirty-three HIV-infected women and 33 non-HIV-infected women who were similar in age (median [interquartile range], 47 [45-48] vs 47 [46-49] y), race (64% vs 52% nonwhite, P = 0.32), and menstrual patterns (number of periods in the past year; 5 [4-9] vs 6 [4-10], P = 0.53) were studied. Perimenopausal HIV-infected women reported greater hot flash severity (HIV vs non-HIV: 2 [1-3] vs 1 [0-3], P = 0.03) and hot flash-related interference (HFRDIS total score, 37 [10-60] vs 6 [0-20], P = 0.001).

conclusionsPerimenopausal HIV-infected women experience greater hot flash severity and related interference compared with non-HIV-infected perimenopausal women. Increased distress secondary to hot flashes may reduce quality of life and negatively impact important health-promoting behaviors, including adherence to antiretroviral therapy, in HIV-infected women.

Indexed as

EthnicityFemaleHIV InfectionsHot FlashesHumansMenopauseMiddle AgedPerimenopauseQuality of LifeSurveys and Questionnaires

Identifiers

PMID23820600
PMCPMC3819412

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.