Evidence map›Paper›PMID 23820122›Full record

ReviewClinical obstetrics and gynecology2013

Maturation and differentiation of the fetal vasculature.

William J Pearce, Omid Khorram

Open access · greenAbstract readReview
In one paragraph

Review in Clinical obstetrics and gynecology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Pathomechanisms of Prenatally Programmed Adult Diseases.Antioxidants (Basel, Switzerland) · 2023
    Review
  2. Review
  3. Article
  4. Postnatal development alters functional compartmentalization of myosin light chain kinase in ovine carotid arteries.American journal of physiology. Regulatory, integrative and comparative physiology · 2021
    Article
  5. Article
  6. Hypoxic modulation of fetal vascular MLCK abundance, localization, and function.American journal of physiology. Regulatory, integrative and comparative physiology · 2021
    Article
  7. Fetal Cerebrovascular Maturation: Effects of Hypoxia.Seminars in pediatric neurology · 2018
    Review
  8. A twin study of cilioretinal arteries, tilted discs and situs inversus.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2018
    Article
  9. Chronic hypoxia alters fetal cerebrovascular responses to endothelin-1.American journal of physiology. Cell physiology · 2017
    Article
  10. Article
  11. VEGF receptors mediate hypoxic remodeling of adult ovine carotid arteries.Journal of applied physiology (Bethesda, Md. : 1985) · 2014
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

William J PearceCenter for Perinatal Biology, Loma Linda University School of Medicine, Loma Linda, CA, USA. wpearce@llu.edu
Omid Khorram
Harbor–UCLA Medical Center · USLoma Linda University · US

Funding

Uterine vascular responses to pregnancy and long term hypoxemiaP01HD031226 · NICHD · LOMA LINDA UNIVERSITY · PI LONGO, LAWRENCE D · 1995 to 2014
$21.4M
MATURATION OF CEREBROVASCULAR RELAXANT MECHANISMSR01HL064867 · NHLBI · LOMA LINDA UNIVERSITY · PI PEARCE, WILLIAM J. · 2000 to 2009
$1.8M
Cerebrovascular Myosin Light Chain Phosphorylation in Fetus, Newborn, and AdultR01NS076945 · NINDS · LOMA LINDA UNIVERSITY · PI PEARCE, WILLIAM J. · 2011 to 2015
$1.5M
MATURATION OF CEREBROVASCULAR CONTRACTILE MECHANISMSR01HL054120 · NHLBI · LOMA LINDA UNIVERSITY · PI PEARCE, WILLIAM J. · 1995 to 2005
$1.2M
NHLBI NIH HHS HL54120NHLBI NIH HHS HL64867NHLBI NIH HHS R01 HL054120NHLBI NIH HHS R01 HL064867NICHD NIH HHS HD31266NICHD NIH HHS P01 HD031226NINDS NIH HHS NS076945NINDS NIH HHS R01 NS076945
6 · The paper itself

Abstract

Rapid postnatal growth and differentiation of fetal arterial smooth muscle is coordinated by a cacophony of growth factors, one of the most important of which is vascular endothelial growth factor (VEGF). In fetal arterial smooth muscle, VEGF influences both the expression and intracellular organization of contractile proteins and helps mediate hypoxic vascular remodeling. Numerous factors influence the expression of VEGF and its receptors, including chronic hypoxia, maternal food restriction, glucocorticoids, and miRNA. Continued study of the coupling between VEGF and transcription factors such as myocardin that govern smooth muscle differentiation, offers great promise for better clinical management of neonates at risk for cardiovascular dysregulation.

Indexed as

Blood VesselsCell DifferentiationEndothelial CellsEndothelium, VascularEpigenesis, GeneticFemaleFetal DevelopmentGene Expression Regulation, DevelopmentalGlucocorticoidsHumansHypoxiaInfant, NewbornInfant, PrematureMaternal Nutritional Physiological PhenomenaMicroRNAsMuscle, Smooth, VascularGlucocorticoidsMicroRNAsReceptors, Vascular Endothelial Growth FactorVascular Endothelial Growth Factor A

Identifiers

PMID23820122
PMCPMC3914998
OpenAlexW2029950119

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.