ArticleOrganogenesis
The use of a novel cardiac bioreactor system in investigating fibroblast physiology and its perspectives.
Article in Organogenesis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 6 citations in OpenAlex.
- Biomimetic Cardiac Tissue Model Enables the Adaption of Human Induced Pluripotent Stem Cell Cardiomyocytes to Physiological Hemodynamic Loads.Analytical chemistry · 2016Article
- Endogenous Optical Signals Reveal Changes of Elastin and Collagen Organization During Differentiation of Mouse Embryonic Stem Cells.Tissue engineering. Part C, Methods · 2015Article
- Origin, development, and differentiation of cardiac fibroblasts.Journal of molecular and cellular cardiology · 2014Review
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2 authors at 1 institution in 1 country.
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Abstract
The physical environment of myocardium, featuring excitation-contraction coupling, constant and efficient provision of nutrient/oxygen and delicate integration of cardiomyocytes and supporting cell population (fibroblasts, endothelial cells), is one of the most complex systems in human body. Numerous studies have demonstrated the significance of physical stimulation in cardiac cell physiology, including the maintenance of contractile function in cardiomyocytes, ( 1) cell alignment and extracellular matrix secretion in fibroblasts and endothelial cells. ( 2) (,) ( 3) In effort to reconstruct the physical environment found in the cardiac niche for routine cell culture use, we have devised a bioreactor system to account for three major forms of physical stimuli, namely, cyclic stretch, electrical stimulation and fluid perfusion. ( 4).
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