Evidence map›Paper›PMID 23820023›Full record

ReviewOrganogenesis

The luminal connection: from animal development to lumopathies.

Robert M Kao

Erratum issuedAbstract readReview
In one paragraph

Review in Organogenesis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
  4. Tissue linkage through adjoining basement membranes: The long and the short term of it.Matrix biology : journal of the International Society for Matrix Biology · 2019
    Review
  5. Reciprocal Spatiotemporally Controlled Apoptosis Regulates Wolffian Duct Cloaca Fusion.Journal of the American Society of Nephrology : JASN · 2018
    Article
  6. Article
  7. Integrins and epithelial cell polarity.Journal of cell science · 2014
    Review
  8. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Robert M KaoDepartments of Molecular and Cellular Biology and Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. rkao@post.harvard.edu

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Interconnection of epithelial tubules is a crucial process during organogenesis. Organisms have evolved sets of molecular and cellular strategies to generate an interconnected tubular network during animal development. Spatiotemporal control of common cellular strategies includes dissolution of the basement membrane, apoptosis, rearrangements of cell adhesion junctions, and mesenchymal-like invasive cellular behaviors prior to tubular interconnection. Different model systems exhibit varying degrees of active invasive-like behaviors that precede tubular interconnection, which may reflect changes in cell polarity or differential adhesive cell states. Studies in this newly-emerging field of tubular interconnections will provide a greater understanding of pediatric diseases and cancer metastasis, as well as generate fundamentally new insights into lumen formation pathology, or lumopathies.

Indexed as

Growth and DevelopmentAnimalsApoptosisBasement MembraneEpitheliumHumansIntercellular JunctionsSpatio-Temporal Analysisinvasive behaviorjuxtapositionkidneyluminal interconnectionlumopathies

Identifiers

PMID23820023
PMCPMC3812284

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.