ArticleWorld journal of emergency surgery : WJES2013
Examining the safety of colon anastomosis on a rat model of ischemia-reperfusion injury.
Article in World journal of emergency surgery : WJES, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 5 citations in OpenAlex.
- Left internal iliac artery stenosis as a risk factor for anastomotic leakage after left-sided colorectal surgery.Frontiers in surgery · 2026Article
- Effects of Lupeol on Intestinal Anastomosis After Experimental Intestinal Ischemia-Reperfusion Injury in Rats.Drug design, development and therapy · 2025Article
- Intraperitoneal BromAcCancers · 2023Article
- Corrective Effect of Verbascoside on Histomorphological Differences and Oxidative Stress in Colon Mucosa of Rats in Which Colon Ischemia-Reperfusion Injury was Induced.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2021Article
- The Effects of Simvastatin on Ischemia Reperfusion Injury in an Experimental Colon Anastomosis Model.The Indian journal of surgery · 2017Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionIntestinal ischemia and reperfusion can impair anastomotic strength. The purpose of this study was to evaluate the safety of delayed colon anastomosis following remote ischemia-reperfusion (IR) injury.
methodsRats divided into two groups underwent bilateral groin incisions, however only the study group had femoral artery clamping to inflict IR injury. Twenty-four hours following this insult, the animals underwent laparotomy, incision of the transverse colon and reanastomosis. End points included anastomotic leakage, strength and histopathological features.
resultsAnastomotic leak among IR animals (22.2%) was not statistically different in comparison to the controls [10.5% (p = 0.40)]. Anastomotic mean burst pressures showed no statistically significant difference [150.6 ± 15.57 mmHg in the control group vs. 159.9 ± 9.88 mmHg in the IR group (p = 0.64)]. The acute inflammatory process in the IR group was similar to controls (p = 0.26), as was the chronic repair process (p = 0.88). There was no significant difference between the inflammation:repair ratios amongst the two groups (p = 0.67).
conclusionPrimary colon repair is safe when performed 24 hours following systemic IR injury.
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