ArticleJournal of the American Chemical Society2013
Reaction products and the X-ray structure of AmpDh2, a virulence determinant of Pseudomonas aeruginosa.
Article in Journal of the American Chemical Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Structural Characterization of Lytic Transglycosylase SltB2 ofACS omega · 2025Article
- Characterization of VldE (Spr1875), a Pneumococcal Two-State l,d-Endopeptidase with a Four-Zinc Cluster in the Active Site.ACS catalysis · 2024Article
- Identification of a putative cell wall-hydrolyzing amidase involved in sporangiospore maturation inJournal of bacteriology · 2024Article
- Metagenomic analysis of hot spring soil for mining a novel thermostable enzybiotic.Applied microbiology and biotechnology · 2024Article
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- Article
- Turnover Chemistry and Structural Characterization of the Cj0843c Lytic Transglycosylase ofBiochemistry · 2021Article
- Integrative structural biology of the penicillin-binding protein-1 fromComputational and structural biotechnology journal · 2021Article
- A type VI secretion system delivers a cell wall amidase to target bacterial competitors.Molecular microbiology · 2020Article
- Structural basis of denuded glycan recognition by SPOR domains in bacterial cell division.Nature communications · 2019Article
- Regulation of AmpC-Driven β-Lactam Resistance in Pseudomonas aeruginosa: Different Pathways, Different Signaling.mSystems · 2019Article
- Cell Wall Hydrolases in Bacteria: Insight on the Diversity of Cell Wall Amidases, Glycosidases and Peptidases Toward Peptidoglycan.Frontiers in microbiology · 2019Review
- Cell-Wall Recycling of the Gram-Negative Bacteria and the Nexus to Antibiotic Resistance.Chemical reviews · 2018Review
- Lytic transglycosylases: concinnity in concision of the bacterial cell wall.Critical reviews in biochemistry and molecular biology · 2017Review
- Deciphering the Nature of Enzymatic Modifications of Bacterial Cell Walls.Chembiochem : a European journal of chemical biology · 2017Article
- Muropeptide Binding and the X-ray Structure of the Effector Domain of the Transcriptional Regulator AmpR of Pseudomonas aeruginosa.Journal of the American Chemical Society · 2017Article
- Article
- Activation by Allostery in Cell-Wall Remodeling by a Modular Membrane-Bound Lytic Transglycosylase from Pseudomonas aeruginosa.Structure (London, England : 1993) · 2016Article
- Orthologous and Paralogous AmpD Peptidoglycan Amidases from Gram-Negative Bacteria.Microbial drug resistance (Larchmont, N.Y.) · 2016Review
- The crystal structure of the major pneumococcal autolysin LytA in complex with a large peptidoglycan fragment reveals the pivotal role of glycans for lytic activity.Molecular microbiology · 2016Article
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Authors and funding
12 authors.
Funding
Abstract
The zinc protease AmpDh2 is a virulence determinant of Pseudomonas aeruginosa, a problematic human pathogen. The mechanism of how the protease manifests virulence is not known, but it is known that it turns over the bacterial cell wall. The reaction of AmpDh2 with the cell wall was investigated, and nine distinct turnover products were characterized by LC/MS/MS. The enzyme turns over both the cross-linked and noncross-linked cell wall. Three high-resolution X-ray structures, the apo enzyme and two complexes with turnover products, were solved. The X-ray structures show how the dimeric protein interacts with the inner leaflet of the bacterial outer membrane and that the two monomers provide a more expansive surface for recognition of the cell wall. This binding surface can accommodate the 3D solution structure of the cross-linked cell wall.
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Registered trials
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