Evidence map›Paper›PMID 23819576›Full record

ArticleBJU international2013

Common prescription medication use and erectile dysfunction: results from the Boston Area Community Health (BACH) survey.

Varant Kupelian, Susan A Hall, John B McKinlay

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BJU international, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 2 pooled it
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Erectile dysfunction in renal failure and transplant patients.Translational andrology and urology · 2019
    Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Varant KupelianNew England Research Institutes, Watertown, MA, USA.
Susan A Hall
John B McKinlay
New England Research Institutes · US

Funding

Trajectories of Urologic Disease: Follow-up of BACHU01DK056842 · NIDDK · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI MCKINLAY, JOHN B · 2001 to 2011
$15.7M
Trajectories of Urologic Disease: Follow-up of BACHR01DK056842 · NIDDK · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI MCKINLAY, JOHN B · 2007 to 2007
$1.2M
Pharmacoepidemiology of Urologic SymptomsR21DK082652 · NIDDK · NEW ENGLAND RESEARCH INSTITUTES, INC. · PI HALL, SUSAN AUDREY · 2009 to 2010
$384k
NIDDK NIH HHS DK 56842NIDDK NIH HHS R01 DK056842NIDDK NIH HHS R21 DK082652NIDDK NIH HHS R21DK082652NIDDK NIH HHS U01 DK056842
6 · The paper itself

Abstract

objectiveTo investigate the association of erectile dysfunction (ED) with commonly used medications including antihypertensive treatment (AHT), psychoactive medication and pain and anti-inflammatory medication. SUBJECTS AND

methodsThe Boston Area Community Health (BACH) survey used a multistage stratified design to recruit a random sample of 2301 men aged 30-79 years. ED was assessed using the five-item International Index of Erectile Function (IIEF-5). Prescription medications, captured using a combination of drug inventory and self-report with a prompt by indication, included in this analysis comprised AHT, psychoactive medication, and pain and anti-inflammatory medication. Logistic regression was used to estimate the odds ratios (ORs) of the association of medication use with ED and to adjust for potential confounders including age, comorbid conditions and sociodemographic and lifestyle factors.

resultsMultivariable analyses showed benzodiazepines (adjusted OR = 2.34, 95% confidence interval [CI]: 1.03, 5.31) and tricyclic antidepressants (adjusted OR = 3.35, 95% CI: 1.09, 10.27) were associated with ED, while no association was observed for serotonin reuptake inhibitors/serotonin-norepinephrine reuptake inhibitors and atypical antipsychotics. The use of AHT, whether in monotherapy or in conjunction with other AHTs, and pain or anti-inflammatory medications were not associated with ED after accounting for confounding factors.

conclusionsResults of the BACH survey suggest adverse effects of some psychoactive medications (benzodiazepines and tricyclic antidepressants). No evidence of an association of AHT or pain and anti-inflammatory medication with ED was observed.

Indexed as

AdultAgedAnalgesicsAntidepressive Agents, TricyclicAntihypertensive AgentsAnti-Inflammatory AgentsBenzodiazepinesBody Mass IndexBostonErectile DysfunctionHealth SurveysHumansLogistic ModelsMaleMiddle AgedMotor ActivityAnalgesicsAntidepressive Agents, TricyclicAntihypertensive AgentsAnti-Inflammatory AgentsBenzodiazepinesepidemiologyerectile dysfunctionpharmaco-epidemiology

Identifiers

PMID23819576
PMCPMC3834242
OpenAlexW1492539045

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.