ArticleInternational journal of data mining and bioinformatics2013
Clinical and molecular models of glioblastoma multiforme survival.
Article in International journal of data mining and bioinformatics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Robust meta-analysis shows that glioma transcriptional subtyping complements traditional approaches.Cellular oncology (Dordrecht, Netherlands) · 2014Pooled it
- MicroRNA-383 promotes reactive oxygen species-induced autophagy via downregulating peroxiredoxin 3 in human glioma U87 cells.Experimental and therapeutic medicine · 2021Article
- Machine learning analysis of TCGA cancer data.PeerJ. Computer science · 2021Article
- ShinyLearner: A containerized benchmarking tool for machine-learning classification of tabular data.GigaScience · 2020Article
- Dissecting and rebuilding the glioblastoma microenvironment with engineered materials.Nature reviews. Materials · 2019Article
- Tumour-specific Causal Inference Discovers Distinct Disease Mechanisms Underlying Cancer Subtypes.Scientific reports · 2019Article
- Curated compendium of human transcriptional biomarker data.Scientific data · 2018Article
- Information-Based Medicine in Glioma Patients: A Clinical Perspective.Computational and mathematical methods in medicine · 2018Review
- A cloud-based workflow to quantify transcript-expression levels in public cancer compendia.Scientific reports · 2016Article
- Effect of Corilagin on the Proliferation and NF-κB in U251 Glioblastoma Cells and U251 Glioblastoma Stem-Like Cells.Evidence-based complementary and alternative medicine : eCAM · 2016Article
- Romo1 is associated with ROS production and cellular growth in human gliomas.Journal of neuro-oncology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Glioblastoma multiforme (GBM), a highly aggressive form of brain cancer, results in a median survival of 12-15 months. For decades, researchers have explored the effects of clinical and molecular factors on this disease and have identified several candidate prognostic markers. In this study, we evaluated the use of multivariate classification models for differentiating between subsets of patients who survive a relatively long or short time. Data for this study came from The Cancer Genome Atlas (TCGA), a public repository containing clinical, treatment, histological and biomolecular variables for hundreds of patients. We applied variable-selection and classification algorithms in a cross-validated design and observed that predictive performance of the resulting models varied substantially across the algorithms and categories of data. The best-performing models were based on age, treatments and global DNA methylation. In this paper, we summarise our findings, discuss lessons learned in analysing TCGA data and offer recommendations for performing such analyses.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.