ArticlePLoS neglected tropical diseases2013
Is zinc concentration in toxic phase plasma related to dengue severity and level of transaminases?
Article in PLoS neglected tropical diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Zinc deficiency in children with Dengue viral infection.Pediatric reports · 2019Article
- Taking a bite out of nutrition and arbovirus infection.PLoS neglected tropical diseases · 2018Review
- A Randomized Controlled Trial of Zinc Supplementation as Adjuvant Therapy for Dengue Viral Infection in Thai Children.International journal of preventive medicine · 2018Article
- Biomarkers of severe dengue disease - a review.Journal of biomedical science · 2015Review
- Acute respiratory failure and active bleeding are the important fatality predictive factors for severe dengue viral infection.PloS one · 2014Article
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4 authors.
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Abstract
objectiveTo determine the relationship between plasma zinc values and the severity of dengue viral infection (DVI) and DVI-caused hepatitis.
methodsA prospective cohort study was conducted during 2008-2010 in hospitalized children aged <15 years confirmed with DVI. Complete blood count, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and zinc values (mcg/dL) were determined twice: first during the toxic phase (Zn1) and secondly two weeks after recovery (Zn2).
results39 patients were enrolled with a mean age of 9.7 ± 3.7 years, and 15/39 diagnosed with dengue shock syndrome (DSS). Zn1 values were lower than Zn2 values [median (IQR): 46.0 (37.0, 58.0) vs 65.0 (58.0, 81.0) mcg/dL, respectively, p <0.01]. Zn1 but not Zn2 values had a negative correlation with AST and ALT (rs = -0.33, p = 0.04 and rs = -0.31, p = 0.05, respectively). Patients with DSS had lower Zn1 but not Zn2 values compared with non-DSS patients [median (IQR) Zn1, 38.0 (30.0, 48.0) vs 52.5 (41.2, 58.7), p = 0.02; Zn2, 61.0 (56.0, 88.0) vs 65.0 (59.5, 77.5), respectively, p = 0.76]. Zn1 values showed a decreasing trend across increasing dengue severity groups (p = 0.02). Age <5 years and DVI-associated diarrhea were associated with low Zn1.
conclusionChildren who had a higher grade of dengue disease severity and liver cell injury had lower Zn1 values. Low Zn1 values were probably caused by loss from diarrhea and from zinc translocating to liver cells.
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