ArticlePLoS neglected tropical diseases2013
Phylogenetic analysis reveals a high prevalence of Sporothrix brasiliensis in feline sporotrichosis outbreaks.
Article in PLoS neglected tropical diseases, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 145 papers, 3 of them syntheses that pooled it.
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Who cites it
145 citing papers in PubMed, 3 syntheses or guidelines pooled it, 330 citations in OpenAlex.
- Systematic review of literature to evaluate global distribution of species of theFrontiers in cellular and infection microbiology · 2024Pooled it
- The Historical Burden of Sporotrichosis in Brazil: a Systematic Review of Cases Reported from 1907 to 2020.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Pooled it
- Sporotrichosis in Mexico.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2021Pooled it
- Unique Genetic Clades and Frequent Zoonotic Transmission of Sporothrix brasiliensis with Reduced Itraconazole Susceptibility.Mycopathologia · 2026Article
- Genome variation of Sporothrix schenckii and Sporothrix brasiliensis.PLoS neglected tropical diseases · 2026Article
- Article
- Cat-transmitted Sporotrichosis: A Clonal Household Outbreak with Atypical Human and Canine Disease Due to Sporothrix brasiliensis.Mycopathologia · 2026Article
- Temporal tendencies and spatial patterns of human sporotrichosis in Rio de Janeiro State, Brazil, 2007 to 2023.Revista do Instituto de Medicina Tropical de Sao Paulo · 2026Article
- Sporothrix brasiliensis Atypical Dimorphism in Tissue.Mycopathologia · 2025Article
- Cryptic Diversity and Ecological Overlap inJournal of fungi (Basel, Switzerland) · 2025Article
- Sporothrix brasiliensis Treatment Failure without Initial Elevated Itraconazole MICs in Felids at Border of Brazil.Emerging infectious diseases · 2025Article
- Veterinary application of LAMP: a simple and visual detection tool for feline sporotrichosis.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- In vitro effects of the new antifungal compound manogepix (APX001) against the three most clinically relevant species of Sporothrix.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Article
- Article
- Dermatologic fungal neglected tropical diseases-Part I. Epidemiology and clinical features.Journal of the American Academy of Dermatology · 2025Review
- Sporothrix davidellisii : A new pathogenic species belonging to the Sporothrix pallida complex.Medical mycology · 2025Article
- Extracutaneous sporotrichosis.Clinical microbiology reviews · 2025Review
- Sporothrix is neglected among the neglected.PLoS pathogens · 2025Article
- Emerging Human Health Problems Caused by Pathogenic and Immuno-activating Fungi.Current topics in microbiology and immunology · 2025Review
- Genetic diversity and molecular evolution of 3-carboxymuconate cyclase (Gp60-70), the major antigen in pathogenicMycology · 2025Article
85 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 6 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sporothrix schenckii, previously assumed to be the sole agent of human and animal sporotrichosis, is in fact a species complex. Recently recognized taxa include S. brasiliensis, S. globosa, S. mexicana, and S. luriei, in addition to S. schenckii sensu stricto. Over the last decades, large epidemics of sporotrichosis occurred in Brazil due to zoonotic transmission, and cats were pointed out as key susceptible hosts. In order to understand the eco-epidemiology of feline sporotrichosis and its role in human sporotrichosis a survey was conducted among symptomatic cats. Prevalence and phylogenetic relationships among feline Sporothrix species were investigated by reconstructing their phylogenetic origin using the calmodulin (CAL) and the translation elongation factor-1 alpha (EF1α) loci in strains originated from Rio de Janeiro (RJ, n = 15), Rio Grande do Sul (RS, n = 10), Paraná (PR, n = 4), São Paulo (SP, n =3) and Minas Gerais (MG, n = 1). Our results showed that S. brasiliensis is highly prevalent among cats (96.9%) with sporotrichosis, while S. schenckii was identified only once. The genotype of Sporothrix from cats was found identical to S. brasiliensis from human sources confirming that the disease is transmitted by cats. Sporothrix brasiliensis presented low genetic diversity compared to its sister taxon S. schenckii. No evidence of recombination in S. brasiliensis was found by split decomposition or PHI-test analysis, suggesting that S. brasiliensis is a clonal species. Strains recovered in states SP, MG and PR share the genotype of the RJ outbreak, different from the RS clone. The occurrence of separate genotypes among strains indicated that the Brazilian S. brasiliensis epidemic has at least two distinct sources. We suggest that cats represent a major host and the main source of cat and human S. brasiliensis infections in Brazil.
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