ArticlePloS one2013
Characterization of pyruvate uptake in Escherichia coli K-12.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
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- Pathway and Production Differences in Branched-Chain Hydroxy Acids as Bioactive Metabolites inInternational journal of molecular sciences · 2024Article
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- Collective peroxide detoxification determines microbial mutation rate plasticity in E. coli.PLoS biology · 2024Article
- Pyruvate Abundance Confounds Aminoglycoside Killing of Multidrug-Resistant Bacteria via Glutathione Metabolism.Research (Washington, D.C.) · 2024Article
- Dynamic fluctuations in a bacterial metabolic network.Nature communications · 2023Article
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- RpuS/R Is a Novel Two-Component Signal Transduction System That Regulates the Expression of the Pyruvate Symporter MctP inFrontiers in microbiology · 2022Article
- Tryptophan Production Maximization in a Fed-Batch Bioreactor with ModifiedBioengineering (Basel, Switzerland) · 2021Article
- Metabolic plasticity enables lifestyle transitions of Porphyromonas gingivalis.NPJ biofilms and microbiomes · 2021Article
- Glucose-Limited Fed-Batch Cultivation Strategy to Mimic Large-Scale Effects inMicroorganisms · 2021Article
- Function and Regulation of the Pyruvate Transporter CstA inInternational journal of molecular sciences · 2020Article
- Profiling Bacterial Diversity and Potential Pathogens in Wastewater Treatment Plants Using High-Throughput Sequencing Analysis.Microorganisms · 2019Article
- Characterization of LrgAB as a stationary phase-specific pyruvate uptake system in Streptococcus mutans.BMC microbiology · 2019Article
- Adaptive laboratory evolution of a genome-reduced Escherichia coli.Nature communications · 2019Article
- Peptide Transporter CstA Imports Pyruvate in Escherichia coli K-12.Journal of bacteriology · 2018Article
- BtsT, a Novel and Specific Pyruvate/HJournal of bacteriology · 2018Article
- A Single-Cell View of the BtsSR/YpdAB Pyruvate Sensing Network in Escherichia coli and Its Biological Relevance.Journal of bacteriology · 2018Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The monocarboxylate pyruvate is an important metabolite and can serve as sole carbon source for Escherichia coli. Although specific pyruvate transporters have been identified in two bacterial species, pyruvate transport is not well understood in E. coli. In the present study, pyruvate transport was investigated under different growth conditions. The transport of pyruvate shows specific activities depending on the growth substrate used as sole carbon source, suggesting the existence of at least two systems for pyruvate uptake: i) one inducible system and probably highly specific for pyruvate and ii) one system active under non-induced conditions. Using the toxic pyruvate analog 3-fluoropyruvate, a mutant was isolated unable to grow on and transport pyruvate. Further investigation revealed that a revertant selected for growth on pyruvate regained the inducible pyruvate transport activity. Characterization of pyruvate excretion showed that the pyruvate transport negative mutant accumulated pyruvate in the growth medium suggesting an additional transport system for pyruvate excretion. The here presented data give valuable insight into the pyruvate metabolism and transport of E. coli suggesting the presence of at least two uptake systems and one excretion system to balance the intracellular level of pyruvate.
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