ArticlePloS one2013
Tripeptidyl peptidase II regulates sperm function by modulating intracellular Ca(2+) stores via the ryanodine receptor.
Article in PloS one, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Physiology and Multi-Omics Provide Insights into Sperm Activation and Movement in Euryhaline Spotted Seabass (Biomolecules · 2026Article
- The systems that transport ions and their impact on sperm function and male fertility.Function (Oxford, England) · 2026Review
- Sperm Motility Is Modulated by FInternational journal of molecular sciences · 2025Article
- Epigenetic determinants of reproductive potential augment the predictive ability of the semen analysis.F&S science · 2023Article
- Can Dietary n-3 Polyunsaturated Fatty Acids Affect Apelin and Resolvin in Testis and Sperm of Male Rabbits?Molecules (Basel, Switzerland) · 2023Article
- IKBA phosphorylation governs human sperm motility through ACC-mediated fatty acid beta-oxidation.Communications biology · 2023Article
- FInternational journal of molecular sciences · 2023Article
- Lysophosphatidic Acid Improves Human Sperm Motility by Enhancing Glycolysis and Activating L-Type Calcium Channels.Frontiers in endocrinology · 2022Article
- CARF promotes spermatogonial self-renewal and proliferation through Wnt signaling pathway.Cell discovery · 2020Article
- DICER1 regulates antibacterial function of epididymis by modulating transcription of β-defensins.Journal of molecular cell biology · 2019Article
- EMC10 governs male fertility via maintaining sperm ion balance.Journal of molecular cell biology · 2018Article
- Pharmacological modulation of the COPharmacology & therapeutics · 2018Review
- Bisphenol A accelerates capacitation-associated protein tyrosine phosphorylation of rat sperm by activating protein kinase A.Acta biochimica et biophysica Sinica · 2016Article
- CCNYL1, but Not CCNY, Cooperates with CDK16 to Regulate Spermatogenesis in Mouse.PLoS genetics · 2015Article
- Impact of precise modulation of reactive oxygen species levels on spermatozoa proteins in infertile men.Clinical proteomics · 2015Article
- Mechanistic target of rapamycin kinase (Asian journal of andrologyArticle
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies have identified Ca(2+) stores in sperm cells; however, it is not clear whether these Ca(2+) stores are functional and how they are mobilized. Here, in vitro and in vivo, we determined that tripeptidyl peptidase II antagonists strongly activated the cAMP/PKA signaling pathway that drives sperm capacitation-associated protein tyrosine phosphorylation. We demonstrated that in the absence of Ca(2+), TPIII antagonists elevated the intracellular Ca(2+) levels in sperm, resulting in a marked improvement in sperm movement, capacitation, acrosome reaction, and the in vitro fertilizing ability. This antagonist-induced release of intracellular Ca(2+) could be blocked by the inhibitors of ryanodine receptors (RyRs) which are the main intracellular Ca(2+) channels responsible for releasing stored Ca(2+). Consistent with these results, indirect immunofluorescence assay using anti-RyR antibodies further validated the presence of RyR3 in the acrosomal region of mature sperm. Thus, TPPII can regulate sperm maturation by modulating intracellular Ca(2+) stores via the type 3 RyR.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.