ArticleInternational journal of nanomedicine2013
Apoptosis of THP-1 macrophages induced by protoporphyrin IX-mediated sonodynamic therapy.
Article in International journal of nanomedicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 70 citations in OpenAlex.
- A Hypoxia-Responsive Single-Atom Sonozyme for Targeted Sonocatalytic Therapy in Alleviating Atherosclerotic Plaque.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Application and Challenge of Metalloporphyrin Sensitizers in Noninvasive Dynamic Tumor Therapy.Molecules (Basel, Switzerland) · 2024Review
- Sonodynamic Therapy for HER2+ Breast Cancer with Iodinated Heptamethine Cyanine-Trastuzumab Conjugate.International journal of molecular sciences · 2024Article
- Sonodynamic therapy for the treatment of atherosclerosis.Journal of pharmaceutical analysis · 2024Review
- A PPIX-binding probe facilitates discovery of PPIX-induced cell death modulation by peroxiredoxin.Communications biology · 2023Article
- Recent Advances for Dynamic-Based Therapy of Atherosclerosis.International journal of nanomedicine · 2023Review
- Review
- Targeted Photodynamic Therapy Using Alloyed Nanoparticle-Conjugated 5-Aminolevulinic Acid for Breast Cancer.Pharmaceutics · 2021Article
- Morphine enhances LPS-induced macrophage apoptosis through a PPARγ-dependent mechanism.Experimental and therapeutic medicine · 2021Article
- Intracranial Sonodynamic Therapy With 5-Aminolevulinic Acid and Sodium Fluorescein: Safety Study in a Porcine Model.Frontiers in oncology · 2021Article
- Sonodynamic therapy inhibits palmitate-induced beta cell dysfunction via PINK1/Parkin-dependent mitophagy.Cell death & disease · 2019Article
- Article
- Ultrasound-based triggered drug delivery to tumors.Drug delivery and translational research · 2018Review
- Protoporphyrin IX-mediated sonodynamic therapy promotes autophagy in vascular smooth muscle cells.Oncology letters · 2017Article
- Synergistic efficacy of ultrasound, sonosensitizers and chemotherapy: a review.Therapeutic delivery · 2017Review
- Berberine-sonodynamic therapy induces autophagy and lipid unloading in macrophage.Cell death & disease · 2017Article
- 5-Aminolevulinic Acid-Mediated Sonodynamic Therapy Inhibits RIPK1/RIPK3-Dependent Necroptosis in THP-1-Derived Foam Cells.Scientific reports · 2016Article
- Microbubbles Enhance the Antitumor Effects of Sinoporphyrin Sodium Mediated Sonodynamic Therapy both In Vitro and In Vivo.International journal of biological sciences · 2015Article
- Sonodynamic effect of hematoporphyrin monomethyl ether on ligature-induced periodontitis in rats.Drug design, development and therapy · 2015Article
- The efficacy and mechanism of apoptosis induction by hypericin-mediated sonodynamic therapy in THP-1 macrophages.International journal of nanomedicine · 2015Article
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Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSonodynamic therapy (SDT) was developed as a localized ultrasound-activated cytotoxic therapy for cancer. The ability of SDT to destroy target tissues selectively is especially appealing for atherosclerotic plaque, in which selective accumulation of the sonosensitizer, protoporphyrin IX (PpIX), had been demonstrated. Here we investigate the effects of PpIX-mediated SDT on macrophages, which are the main culprit in progression of atherosclerosis. METHODS AND
resultsCultured THP-1 derived macrophages were incubated with PpIX. Fluorescence microscopy showed that the intracellular PpIX concentration increased with the concentration of PpIX in the incubation medium. MTT assay demonstrated that SDT with PpIX significantly decreased cell viability, and this effect increased with duration of ultrasound exposure and PpIX concentration. PpIX-mediated SDT induced both apoptosis and necrosis, and the maximum apoptosis to necrosis ratio was obtained after SDT with 20 μg/mL PpIX and five minutes of sonication. Production of intracellular singlet oxygen and secondary disruption of the cytoskeleton were also observed after SDT with PpIX.
conclusionPpIX-mediated SDT had apoptotic effects on THP-1 macrophages via generation of intracellular singlet oxygen and disruption of the cytoskeleton. PpIX-mediated SDT may be a potential treatment to attenuate progression of atherosclerotic plaque.
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