Evidence map›Paper›PMID 23818500›Full record

ReviewCold Spring Harbor perspectives in biology2013

Epigenetics in Saccharomyces cerevisiae.

Michael Grunstein, Susan M Gasser

Abstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.

0numbers the graph read from it
0cells of the map it votes in
63citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

63 citing papers in PubMed.

  1. Article
  2. Review
  3. A Translocation within thebioRxiv : the preprint server for biology · 2026
    Article
  4. Review
  5. Genome sequence assembly and annotation ofNAR genomics and bioinformatics · 2025
    Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Review
  11. Context-dependent function of the transcriptional regulator Rap1 in gene silencing and activation inProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  12. Article
  13. Article
  14. The histone code of the fungal genusMicrobial genomics · 2022
    Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. DNA Methyltransferases Regulate Pathogenicity ofJournal of fungi (Basel, Switzerland) · 2021
    Article
  20. Article

3 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Michael GrunsteinUniversity of California, Los Angeles, Los Angeles, California 90095, USA.
Susan M Gasser

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Saccharomyces cerevisiae provides a well-studied model system for heritable silent chromatin, in which a nonhistone protein complex--the SIR complex--represses genes by spreading in a sequence-independent manner, much like heterochromatin in higher eukaryotes. The ability to study mutations in histones and to screen genome-wide for mutations that impair silencing has yielded an unparalleled depth of detail about this system. Recent advances in the biochemistry and structural biology of the SIR-chromatin complex bring us much closer to a molecular understanding of how Sir3 selectively recognizes the deacetylated histone H4 tail and demethylated histone H3 core. The existence of appropriate mutants has also shown how components of the silencing machinery affect physiological processes beyond transcriptional repression.

Indexed as

Gene SilencingModels, GeneticAcetylationDNA ReplicationEvolution, MolecularHeterochromatinHistonesSaccharomyces cerevisiaeSilent Information Regulator Proteins, Saccharomyces cerevisiaeHeterochromatinHistonesSilent Information Regulator Proteins, Saccharomyces cerevisiaeSIR4 protein, S cerevisiae

Identifiers

PMID23818500
PMCPMC3685889

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.