Evidence map›Paper›PMID 23818497›Full record

ReviewCold Spring Harbor perspectives in biology2013

Principles and concepts of DNA replication in bacteria, archaea, and eukarya.

Michael O'Donnell, Lance Langston, Bruce Stillman

Open access · bronzeAbstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 222 papers.

0numbers the graph read from it
0cells of the map it votes in
222citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

222 citing papers in PubMed, 374 citations in OpenAlex.

  1. Article
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  8. ThebioRxiv : the preprint server for biology · 2026
    Article
  9. Article
  10. Article
  11. Review
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Eukaryotic Lagging Strand Synthesis is Distributive.bioRxiv : the preprint server for biology · 2025
    Article
  20. DNA polymerase α-primase can function as a translesion DNA polymerase.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article

162 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Michael O'DonnellThe Rockefeller University and Howard Hughes Medical Institute, New York, New York 10065, USA.
Lance Langston
Bruce Stillman
Cold Spring Harbor Laboratory · USHoward Hughes Medical Institute · US

Funding

Single-Cell Biology Shared ResourceP30CA045508 · NCI · COLD SPRING HARBOR LABORATORY · PI John Edward Moses · 1987 to 2026
$118.9M
VIRAL TRANSACTIVATIONP01CA013106 · NCI · COLD SPRING HARBOR LABORATORY · PI Camila dos Santos · 1985 to 2026
$116.8M
REGULATION OF DNA REPLICATIONR01GM045436 · NIGMS · COLD SPRING HARBOR LABORATORY · PI STILLMAN, BRUCE W. · 1991 to 2025
$15.8M
BIOCHEMICAL MECHANISM OF DNA POLYMERASE III HOLOENZYMER01GM038839 · NIGMS · WEILL MEDICAL COLLEGE OF CORNELL UNIV · PI O'DONNELL, MICHAEL E · 1988 to 2014
$2.9M
BIOCHEMICAL MECHANISM OF DNA POLYMERASE III HOLOENZYMER37GM038839 · NIGMS · ROCKEFELLER UNIVERSITY · PI O'DONNELL, MICHAEL E · 1997 to 2006
$2.2M
Howard Hughes Medical InstituteNCI NIH HHS CA13016NCI NIH HHS P01 CA013106NCI NIH HHS P30 CA045508NIGMS NIH HHS GM38839NIGMS NIH HHS GM45436NIGMS NIH HHS R01 GM038839NIGMS NIH HHS R01 GM045436NIGMS NIH HHS R37 GM038839
6 · The paper itself

Abstract

The accurate copying of genetic information in the double helix of DNA is essential for inheritance of traits that define the phenotype of cells and the organism. The core machineries that copy DNA are conserved in all three domains of life: bacteria, archaea, and eukaryotes. This article outlines the general nature of the DNA replication machinery, but also points out important and key differences. The most complex organisms, eukaryotes, have to coordinate the initiation of DNA replication from many origins in each genome and impose regulation that maintains genomic integrity, not only for the sake of each cell, but for the organism as a whole. In addition, DNA replication in eukaryotes needs to be coordinated with inheritance of chromatin, developmental patterning of tissues, and cell division to ensure that the genome replicates once per cell division cycle.

Indexed as

Models, GeneticArchaeaBacteriaDNA DamageDNA ReplicationEukaryota

Identifiers

PMID23818497
PMCPMC3685895
OpenAlexW2125003792

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.