ArticleChromosoma2013
Chromatin in a marine picoeukaryote is a disordered assemblage of nucleosomes.
Article in Chromosoma, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 65 citations in OpenAlex.
- In-cell chromatin structure by Cryo-FIB and Cryo-ET.Current opinion in structural biology · 2025Review
- Nanoscale analysis of human G1 and metaphase chromatin in situ.The EMBO journal · 2025Article
- Structure of native chromatin fibres revealed by Cryo-ET in situ.Nature communications · 2023Article
- Review
- Article
- The Dynamic Influence of Linker Histone Saturation within the Poly-Nucleosome Array.Journal of molecular biology · 2021Article
- Article
- Cryo-nanoscale chromosome imaging-future prospects.Biophysical reviews · 2020Review
- Near-atomic resolution structures of interdigitated nucleosome fibres.Nature communications · 2020Article
- Investigating eukaryotic cells with cryo-ET.Molecular biology of the cell · 2020Article
- Mitotic chromosome organization: General rules meet species-specific variability.Computational and structural biotechnology journal · 2020Review
- Chromatin fiber structural motifs as regulatory hubs of genome function?Essays in biochemistry · 2019Review
- Cryo-ET reveals the macromolecular reorganization ofProceedings of the National Academy of Sciences of the United States of America · 2018Article
- The in situ structures of mono-, di-, and trinucleosomes in human heterochromatin.Molecular biology of the cell · 2018Article
- Nucleosome conformational variability in solution and in interphase nuclei evidenced by cryo-electron microscopy of vitreous sections.Nucleic acids research · 2018Article
- Natural chromatin is heterogeneous and self-associates in vitro.Molecular biology of the cell · 2018Article
- Cryo-EM of nucleosome core particle interactions in trans.Scientific reports · 2018Article
- The 10-nm chromatin fiber and its relationship to interphase chromosome organization.Biochemical Society transactions · 2018Review
- Chromatin as a nuclear spring.Biophysics and physicobiology · 2018Review
- Nucleosome-nucleosome interactions via histone tails and linker DNA regulate nuclear rigidity.Molecular biology of the cell · 2017Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Chromatin organization is central to many conserved biological processes, but it is generally unknown how the underlying nucleosomes are arranged in situ. Here, we have used electron cryotomography to study chromatin in the picoplankton Ostreococcus tauri, the smallest known free-living eukaryote. By visualizing the nucleosome densities directly, we find that O. tauri chromosomes do not arrange into discrete, compact bodies or any other higher level of order. In contrast to the textbook 30-nm fiber model, O. tauri chromatin resembles a disordered assemblage of nucleosomes akin to the polymer melt model. This disorganized nucleosome arrangement has important implications for potentially conserved functions in tiny eukaryotes such as the clustering of nonhomologous chromosomes at the kinetochore during mitosis and the independent regulation of closely positioned adjacent genes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.