ArticleAmerican journal of physical anthropology2013
Brief communication: Adrenal androgens and aging: Female chimpanzees (Pan troglodytes) compared with women.
Article in American journal of physical anthropology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 25 citations in OpenAlex.
- Dehydroepiandrosterone (DHEA) as a tool for conservation.Environmental monitoring and assessment · 2026Review
- Contemporary small-scale subsistence populations offer unique insights into human musculoskeletal health and aging.Science advances · 2024Review
- Comparative physiological anthropogeny: exploring molecular underpinnings of distinctly human phenotypes.Physiological reviews · 2023Review
- The novel use of urinary androgens to optimise detection of the fertile window in giant pandas.Reproduction & fertility · 2022Article
- Article
- Multi-system physiological dysregulation and ageing in a subsistence population.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- DHEAS and Human Development: An Evolutionary Perspective.Frontiers in endocrinology · 2020Article
- Detection of a novel, primate-specific 'kill switch' tumor suppression mechanism that may fundamentally control cancer risk in humans: an unexpected twist in the basic biology of TP53.Endocrine-related cancer · 2018Review
- Dehydroepiandrosterone-sulfate (DHEA-S), sex, and age in zoo-housed western lowland gorillas (Gorilla gorilla gorilla).Primates; journal of primatology · 2017Article
- Genomic evidence for the evolution of human postmenopausal longevity.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Oocyte ageing and epigenetics.Reproduction (Cambridge, England) · 2015Review
- Development of adrenal cortical zonation and expression of key elements of adrenal androgen production in the chimpanzee (Pan troglodytes) from birth to adulthood.Molecular and cellular endocrinology · 2014Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Ovarian cycling continues to similar ages in women and chimpanzees yet our nearest living cousins become decrepit during their fertile years and rarely outlive them. Given the importance of estrogen in maintaining physiological systems aside from fertility, similar ovarian aging in humans and chimpanzees combined with somatic aging differences indicates an important role for nonovarian estrogen. Consistent with this framework, researchers have nominated the adrenal androgen dehydroepiandrosterone (DHEA) and its sulfate (DHEAS), which can be peripherally converted to estrogen, as a biomarker of aging in humans and other primates. Faster decline in production of this steroid with age in chimpanzees could help explain somatic aging differences. Here, we report circulating levels of DHEAS in captive female chimpanzees and compare them with published levels in women. Instead of faster, the decline is slower in chimpanzees, but from a much lower peak. Levels reported for other great apes are lower still. These results point away from slowed decline but toward increased DHEAS production as one of the mechanisms underlying the evolution of human longevity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.