Evidence map›Paper›PMID 23818131›Full record

ReviewPharmacological reviews2013

The pharmacology of regenerative medicine.

George J Christ, Justin M Saul, Mark E Furth, Karl-Erik Andersson

Open access · bronzeAbstract readReview
In one paragraph

Review in Pharmacological reviews, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 60 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Autologous hGMSC-Derived iPS: A New Proposal for Tissue Regeneration.International journal of molecular sciences · 2024
    Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Current Status of Alginate in Drug Delivery.Advances in pharmacological and pharmaceutical sciences · 2020
    Review
  18. Review
  19. Article
  20. Regenerative pharmacology in urology.Investigative and clinical urology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

George J ChristWake Forest Institute for Regenerative Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27101, USA. gchrist@wakehealth.edu
Justin M Saul
Mark E Furth
Karl-Erik Andersson
Miami University · USAtrium Health Wake Forest Baptist · US

Funding

Regeneration, Repair and Remodeling of the Lower Urinary Tract P20DK097806 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MARINI, FRANK C. · 2012 to 2015
$1.5M
Keratin hydrogel matrix for tunable growth factor delivery in bone regenerationR01AR061391 · NIAMS · MIAMI UNIVERSITY OXFORD · PI SAUL, JUSTIN · 2012 to 2015
$1.4M
Novel Studies of Bladder Regeneration in a Rodent ModelR21DK081832 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI CHRIST, GEORGE JOSEPH · 2008 to 2009
$508k
NIAMS NIH HHS R01 AR061391NIDDK NIH HHS DK081832NIDDK NIH HHS DK097806NIDDK NIH HHS P20 DK097806NIDDK NIH HHS R21 DK081832
6 · The paper itself

Abstract

Regenerative medicine is a rapidly evolving multidisciplinary, translational research enterprise whose explicit purpose is to advance technologies for the repair and replacement of damaged cells, tissues, and organs. Scientific progress in the field has been steady and expectations for its robust clinical application continue to rise. The major thesis of this review is that the pharmacological sciences will contribute critically to the accelerated translational progress and clinical utility of regenerative medicine technologies. In 2007, we coined the phrase "regenerative pharmacology" to describe the enormous possibilities that could occur at the interface between pharmacology, regenerative medicine, and tissue engineering. The operational definition of regenerative pharmacology is "the application of pharmacological sciences to accelerate, optimize, and characterize (either in vitro or in vivo) the development, maturation, and function of bioengineered and regenerating tissues." As such, regenerative pharmacology seeks to cure disease through restoration of tissue/organ function. This strategy is distinct from standard pharmacotherapy, which is often limited to the amelioration of symptoms. Our goal here is to get pharmacologists more involved in this field of research by exposing them to the tools, opportunities, challenges, and interdisciplinary expertise that will be required to ensure awareness and galvanize involvement. To this end, we illustrate ways in which the pharmacological sciences can drive future innovations in regenerative medicine and tissue engineering and thus help to revolutionize the discovery of curative therapeutics. Hopefully, the broad foundational knowledge provided herein will spark sustained conversations among experts in diverse fields of scientific research to the benefit of all.

Indexed as

PharmacologyRegenerative MedicineAnimalsBiocompatible MaterialsHumansStem Cell TransplantationTissue EngineeringBiocompatible Materials

Identifiers

PMID23818131
PMCPMC3698935
OpenAlexW2145393848

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.