SynthesisJournal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract2013
Factors associated with lymph node metastasis in radically resected rectal carcinoids: a systematic review and meta-analysis.
Synthesis in Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- Fear of Cancer Recurrence Prevalence and Its Associated Factors Among Family Caregivers of Women With Breast Cancer: A Systematic Review and Meta-Analysis.Journal of clinical nursing · 2025Pooled it
- Traction-assisted endoscopic submucosal resection (TA-ESD) for rectal neuroendocrine tumors: a randomized multi-center trial.Surgical endoscopy · 2025Trial
- Current status of endoscopic resection for small rectal neuroendocrine tumors.World journal of gastroenterology · 2025Review
- Evaluation of the details and importance of lymphatic, microvascular, and perineural invasion in patients with non-functioning pancreatic neuroendocrine neoplasms based on tumor size and the 2022 World Health Organization classification: a 23-year retrospective analysis.World journal of surgical oncology · 2025Article
- The importance of microvascular invasion in patients with non-functioning pancreatic neuroendocrine neoplasm.Langenbeck's archives of surgery · 2024Article
- Risk Factors for Lymph Node Metastasis of Rectal Neuroendocrine Tumor and Its Prognostic Impact: A Single-Center Retrospective Analysis of 195 Cases with Radical Resection.Annals of surgical oncology · 2023Article
- Lymph Node Metastasis, Radical Surgery, and Prognosis in Well-Differentiated Neuroendocrine Tumors of the Rectum.Annals of surgical oncology · 2023Article
- Different miRNAs Related toInternational journal of molecular sciences · 2023Article
- Risk factors and clinical outcomes of incomplete endoscopic resection of small rectal neuroendocrine tumors in southern China: a 9-year data analysis.Gastroenterology report · 2023Article
- State of the Art in Endoscopic Therapy for the Management of Gastroenteropancreatic Neuroendocrine Tumors.Current treatment options in oncology · 2022Review
- Risk factors for lymph node metastasis and prognosis in colorectal neuroendocrine tumours.International journal of colorectal disease · 2022Article
- Assessment of the Risk of Nodal Involvement in Rectal Neuroendocrine Neoplasms: The NOVARA Score, a Multicentre Retrospective Study.Journal of clinical medicine · 2022Article
- Risk Factors Associated with the Development of Metastases in Patients with Gastroenteropancreatic Neuroendocrine Tumors: A Retrospective Analysis.Journal of clinical medicine · 2021Article
- Prognosis of rectal neuroendocrine tumors after endoscopic resection: a single-center retrospective study.Journal of gastrointestinal oncology · 2021Article
- Rectal neuroendocrine tumor with extracapsular lymph node metastasis: a case report.Clinical journal of gastroenterology · 2021Article
- Outcomes for a Large Cohort of Patients with Rectal Neuroendocrine Tumors: an Analysis of the National Cancer Database.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2021Article
- Difficulty of predicting lymph node metastasis on CT in patients with rectal neuroendocrine tumors.PloS one · 2019Article
- Curative and palliative surgery in patients with neuroendocrine tumors of the gastro-entero-pancreatic (GEP) tract.Reviews in endocrine & metabolic disorders · 2018Review
- Lymphovascular invasion in more than one-quarter of small rectal neuroendocrine tumors.World journal of gastroenterology · 2016Article
- A case of rectal carcinoid, 7 mm in diameter, with skip metastasis to the lateral lymph node.Molecular and clinical oncology · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlthough various guidelines regarding neuroendocrine tumors were released, treatment for rectal neuroendocrine tumors with size between 1 and 2 cm has not been explicitly elucidated. The determinant factor of the choice between endoscopic resection and radical surgery is whether lymph node involvement exists.
aimThis study aims to explore factors associated with lymph node involvement in rectal neuroendocrine tumors by conducting a meta-analysis.
methodsA broad literature research of Pubmed, Embase&Medline, and The Cochrane Library was performed, and systematic review and meta-analysis about factors associated with lymph node involvement were conducted.
resultsSeven studies were included in this meta-analysis. Tumor size > 1 cm (odds ratio (OR) 6.72, 95% confidence interval (CI) [3.23, 14.02]), depth of invasion (OR 5.06, 95% CI [2.30, 11.10]), venous invasion (OR 5.92, 95% CI [2.21, 15.87]), and central depression (OR 3.00, 95% CI [1.07, 8.43]) were significantly associated with lymph node involvement.
conclusionThe available clinical evidence suggests that tumor size > 1 cm, invasion of muscularis properia, venous invasion, and central depression could be risk factors of lymph node involvement, while other factors reported by few studies need further research.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.