ArticleJournal of orthopaedic research : official publication of the Orthopaedic Research Society2013
Mechanical properties of the extra-fibrillar matrix of human annulus fibrosus are location and age dependent.
Article in Journal of orthopaedic research : official publication of the Orthopaedic Research Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Decoding intervertebral disc degeneration pathomechanics: from mechanisms to therapeutic horizons.Journal of advanced research · 2026Review
- Global and local identifiability analysis of a nonlinear biphasic constitutive model in confined compression.Journal of the Royal Society, Interface · 2024Article
- Age and gender differences in lumbar intervertebral disk strain using mechanical loading magnetic resonance imaging.NMR in biomedicine · 2023Article
- A Microstructure-Based Mechanistic Approach to Detect Degeneration Effects on Potential Damage Zones and Morphology of Young and Old Human Intervertebral Discs.Annals of biomedical engineering · 2023Article
- MRI-based measurement of in vivo disc mechanics in a young population due to flexion, extension, and diurnal loading.JOR spine · 2023Article
- Development of a Computational Model of the Mechanical Behavior of the L4-L5 Lumbar Spine: Application to Disc Degeneration.Materials (Basel, Switzerland) · 2022Article
- Variation in surgical treatment of degenerative spondylolisthesis in Canada: surgeon assessment of stability and impact on treatment.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2021Article
- Mechanical Stimulation and Diameter of Fiber Scaffolds Affect the Differentiation of Rabbit Annulus Fibrous Stem Cells.Tissue engineering and regenerative medicine · 2021Article
- Biomaterials-Induced Stem Cells Specific Differentiation Into Intervertebral Disc Lineage Cells.Frontiers in bioengineering and biotechnology · 2020Review
- Strategies for Annulus Fibrosus Regeneration: From Biological Therapies to Tissue Engineering.Frontiers in bioengineering and biotechnology · 2018Review
- Annulus fibrosus functional extrafibrillar and fibrous mechanical behaviour: experimental and computational characterisation.Royal Society open science · 2017Article
- Tissue Engineering of the Intervertebral Disc's Annulus Fibrosus: A Scaffold-Based Review Study.Tissue engineering and regenerative medicine · 2017Review
- Collagen V expression is crucial in regional development of the supraspinatus tendon.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2016Article
- Molecular mechanisms of biological aging in intervertebral discs.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2016Review
- Multiscale regression modeling in mouse supraspinatus tendons reveals that dynamic processes act as mediators in structure-function relationships.Journal of biomechanics · 2016Article
- Derivation of inter-lamellar behaviour of the intervertebral disc annulus.Journal of the mechanical behavior of biomedical materials · 2015Article
- Elastic, permeability and swelling properties of human intervertebral disc tissues: A benchmark for tissue engineering.Journal of biomechanics · 2014Article
- Regional variations in the cellular, biochemical, and biomechanical characteristics of rabbit annulus fibrosus.PloS one · 2014Article
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Authors and funding
4 authors.
Funding
Abstract
The mechanical behavior of the annulus fibrosus (AF) of the intervertebral disc can be modeled as a mixture of fibers, extra-fibrillar matrix (EFM), ions, and fluid. However, the properties of the EFM have not been measured directly. We measured mechanical properties of the human EFM at several locations, determined the effect of age and degeneration, and evaluated whether changes in EFM properties correspond to AF compositional changes. EFM mechanical properties were measured using a method that combines osmotic loading and confined compression. AF samples were dissected from several locations, and mechanical properties were correlated with age, degeneration, and composition. EFM modulus was found to range between 10 and 50 kPa, increasing nonlinearly with compression magnitude and being highest in the AF outer-anterior region. EFM properties were not correlated with composition or degeneration. However, the EFM modulus, its relative contribution to tissue modulus, and model parameters were correlated with age. These measurements will result in more accurate predictions of deformations in the intervertebral disc. Additionally, parameters such as permeability and diffusivity used for biotransport analysis of glucose and other solutes depend on EFM deformation. Consequently, the accuracy of biotransport simulations will be greatly improved.
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