SynthesisZeitschrift fur Rheumatologie2013
Lack of association between the haplotype GCC/ATA polymorphism in the IL-10 promoter and SLE risk: evidence from a meta-analysis.
Synthesis in Zeitschrift fur Rheumatologie, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed, 2 citations in OpenAlex.
- Pathologic patterns of interleukin 10 expression--a review.Biochemia medica · 2015Review
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Authors and funding
3 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Numerous studies have investigated the association between the interleukin (IL)-10 promoter haplotype GCC/ATA (at the - 1082, - 819 and - 592 positions of the IL-10 gene) polymorphism and systemic lupus erythematosus (SLE) risk, but the results were inconsistent. We performed the current meta-analysis to assess precisely the association by comparing the GCC haplotype with the ATA haplotype. A literature search was conducted using Pubmed and Web of Science databases. Twelve studies including 1765 cases and 2444 controls were included in this meta-analysis. The overall odds ratios (total and stratified by ethnicity: Asian or Caucasian) were 1.042 (95 % confidence interval [CI] 0.893-1.216; p = 0.599), 0.790 (95 % CI 0.528-1.182; p = 0.251), and 1.093 (95 % CI 0.919-1.300; p = 0.317), respectively. The results indicated that the GCC haplotype revealed no statistically significant association with SLE risk; thus, the haplotype GCC/ATA polymorphism of the IL-10 promoter is not likely to be involved in SLE susceptibility.
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