ReviewEndocrine2014
Anti-hypertensive treatment in pheochromocytoma and paraganglioma: current management and therapeutic features.
Review in Endocrine, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.
- What should we focus on in pregnancy complicated by pheochromocytoma? a bibliometric analysis (1990-2024).Frontiers in oncology · 2025Pooled it
- Approach to the Preoperative Pharmacological Management of Catecholamine-Secreting Tumors in Children: A Case Series and Review.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2026Article
- Hypertensive retinopathy as the first manifestation of extra-adrenal paraganglioma.Hormones (Athens, Greece) · 2025Article
- A case report of blood pressure fluctuation, inverted Takotsubo cardiomyopathy, and pulmonary embolism: searching for a link.European heart journal. Case reports · 2025Article
- A case of successful management for spontaneous rupture of paraganglioma treated with preoperative transcatheter arterial embolization.Surgical case reports · 2024Article
- Adrenoceptors and Hypertension.Handbook of experimental pharmacology · 2024Review
- Surgical Management of Acute Appendicitis in a Patient with Diagnosed but "Unprepared" Pheochromocytoma: A Case Report.Sisli Etfal Hastanesi tip bulteni · 2024Article
- Surgical management of recurrent and extra-adrenal pheochromocytomas requiring vascular resection and reconstruction.Journal of vascular surgery cases and innovative techniques · 2023Article
- Article
- Review
- Paraganglioma in pregnancy: A case series and literature review.Obstetric medicine · 2022Review
- Perioperative control of paroxysmal hypertension using esmolol with alpha-blockade in a child with a germline mutated paraganglioma.Endocrinology, diabetes & metabolism case reports · 2021Article
- Malignant pheochromocytoma: pain, palpitation, perspiration and perplexities.BMJ case reports · 2021Article
- Metastatic Pheochromocytomas and Abdominal Paragangliomas.The Journal of clinical endocrinology and metabolism · 2021Review
- Cardiac arrest complicating cardiogenic shock: from pathophysiological insights to Impella-assisted cardiopulmonary resuscitation in a pheochromocytoma-induced Takotsubo cardiomyopathy-a case report.European heart journal. Case reports · 2021Article
- Pheochromocytoma as a cause of repeated acute myocardial infarctions, heart failure, and transient erythrocytosis: A case report and review of the literature.World journal of clinical cases · 2021Article
- Changes in the Size of a Ruptured Pheochromocytoma after Transcatheter Arterial Embolization.Case reports in medicine · 2021Article
- Application of data mining for predicting hemodynamics instability during pheochromocytoma surgery.BMC medical informatics and decision making · 2020Article
- Pheochromocytoma and paraganglioma-an update on diagnosis, evaluation, and management.Pediatric nephrology (Berlin, Germany) · 2020Review
- Clinical Outcome of Carotid Body Paraganglioma Management: A Review of 10-Year Experience.Journal of oncology · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pheochromocytoma (PH) and paraganglioma (PG) are neuroendocrine neoplasms arising from chromaffin cells of the adrenal medulla and the sympathetic ganglia, respectively. Although are unusual cause of hypertension (HT) accounting for at most 0.1-0.2 % of cases, they may lead to severe and potentially lethal hypertensive crisis due to the effects of the released catecholamines. However, both PH and PG may be asymptomatic as ~30 % of subjects are normotensive or have orthostatic hypotension and in these cases the 24 h ambulatory blood pressure (BP) monitoring is an important toll to diagnose and treat HT. HT treatment may be difficult when PH or PG occurs in pregnancy or in the elderly subjects and in these cases a multidisciplinary team is required. When surgical excision is mandatory the perioperative management requires the administration of selective α1-adrenergic blocking agents (i.e., doxazosin, prazosin or terazosin) followed by a β-adrenergic blockade (i.e., propranolol, atenolol). This latter should never be started first because blockade of vasodilatory peripheral β-adrenergic receptors with unopposed α-adrenergic receptor stimulation can lead to a further elevation of BP. Although labetalol is traditionally considered the ideal agent due to its α- and β-adrenergic antagonism, experimental studies do not support its use in this clinical setting. As second regimen, the administration of vasodilators as calcium channel blockers (i.e., nicardipine, nifedipine) may be required to control BP. Oral and sublingual short-acting nifedipine are potentially dangerous in patients with hypertensive emergencies and are not recommend. The latest evidences into the diagnosis and treatment of hypertensive crisis due to PH and PG are reviewed here.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.