ArticleAnnals of biomedical engineering2013
Age-dependent ascending aorta mechanics assessed through multiphase CT.
Article in Annals of biomedical engineering, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Quantifying In Vivo Arterial Deformation from CT and MRI: A Systematic Review of Segmentation, Motion Tracking, and Kinematic Metrics.Bioengineering (Basel, Switzerland) · 2026Review
- Multiscale structure and function of the aortic valve apparatus.Physiological reviews · 2024Review
- Restoration of flow in the aorta: a novel therapeutic target in aortic valve intervention.Nature reviews. Cardiology · 2024Review
- Aortic flow is associated with aging and exercise capacity.European heart journal open · 2023Article
- Magnetic Resonance Imaging and Computed Tomography for the Noninvasive Assessment of Arterial Aging: A Review by the VascAgeNet COST Action.Journal of the American Heart Association · 2023Review
- Ascending Aortic Aneurysm in an Asymptomatic Young Woman Without Risk Factors.CASE (Philadelphia, Pa.) · 2023Article
- The association between pulmonary artery enlargement and mortality in an Emergency Department population undergoing computed tomography pulmonary angiography.Pulmonary circulation · 2023Article
- Age-dependent phenotypic modulation of smooth muscle cells in the normal ascending aorta.Frontiers in cardiovascular medicine · 2023Article
- Biomechanics of Transcatheter Aortic Valve Replacement Complications and Computational Predictive Modeling.Structural heart : the journal of the Heart Team · 2022Review
- Synthesis of multidimensional pathophysiological process leading to type A aortic dissection: a narrative review.Journal of thoracic disease · 2021Review
- Assessment of thoracic aorta in different cardiac phases in patients with non-aorta diseases using cardiac CT.Scientific reports · 2021Article
- Identification of in vivo nonlinear anisotropic mechanical properties of ascending thoracic aortic aneurysm from patient-specific CT scans.Scientific reports · 2019Article
- Three-dimensional thoracic aorta principal strain analysis from routine ECG-gated computerized tomography: feasibility in patients undergoing transcatheter aortic valve replacement.BMC cardiovascular disorders · 2018Article
- Age-related Impairment of Vascular Structure and Functions.Aging and disease · 2017Review
- Postmortem CT morphometry of great vessels with regard to the cause of death for investigating terminal circulatory status in forensic autopsy.International journal of legal medicine · 2015Article
- Relation of murine thoracic aortic structural and cellular changes with aging to passive and active mechanical properties.Journal of the American Heart Association · 2015Article
- Longitudinal and circumferential strain of the proximal aorta.Journal of the American Heart Association · 2014Article
- Computational modeling of cardiac valve function and intervention.Annual review of biomedical engineering · 2014Review
- Predictive biomechanical analysis of ascending aortic aneurysm rupture potential.Acta biomaterialia · 2013Article
- Aortic Aneurysm Mimicking Inferior ST-Elevation Myocardial Infarction: A Case Report.Journal of investigative medicine high impact case reportsArticle
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Authors and funding
5 authors.
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Abstract
Quantification of the age- and gender-specific in vivo mechanical characteristics of the ascending aorta (AA) will allow for identification of abnormalities aside from changes brought on by aging alone. Multiphase clinical CT scans of 45 male patients between the ages of 30 and 79 years were analyzed to assess age-dependent in vivo AA characteristics. The three-dimensional AA geometry for each patient was reconstructed from the CT scans for 9-10 phases throughout the cardiac cycle. The AA circumference was measured during each phase and was used to determine the corresponding diameter, circumferential strain, and wall tension at each phase. The pressure-strain modulus was also determined for each patient. The mean diastolic AA diameter was significantly smaller among young (42.6 ± 5.2 years) at 29.9 ± 2.8 mm than old patients (69.0 ± 5.2 years) at 33.2 ± 3.2 mm. The circumferential AA strain from end-diastole to peak-systole decreased from 0.092 ± 0.03 in young to 0.056 ± 0.03 in old patients. The pressure-strain modulus increased two-fold from 68.4 ± 30.5 kPa in young to 162.0 ± 93.5 kPa in old patients, and the systolic AA wall tension increased from 268.5 ± 31.3 kPa in young to 304.9 ± 49.2 kPa in old patients. The AA dilates and stiffens with aging which increases the vessel wall tension, likely predisposing aneurysm and dissection.
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