ArticleJournal of biomedical optics2013
Overconstrained library-based fitting method reveals age- and disease-related differences in transcutaneous Raman spectra of murine bones.
Article in Journal of biomedical optics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Machine learning reconstruction of digit bone Raman spectra enables noninvasive transcutaneous detection of systemic osteoporosis.Biomedical optics express · 2026Article
- Predicting bone aging using spatially offset Raman spectroscopy: a longitudinal analysis on mice.Analytical and bioanalytical chemistry · 2025Article
- In Vivo Assessment of Bone Quality Without X-rays.Current osteoporosis reports · 2024Review
- Detection of osteoporotic-related bone changes and prediction of distal radius strength using Raman spectra from excised human cadaver finger bones.Journal of biomechanics · 2023Article
- Article
- Compositional assessment of bone by Raman spectroscopy.The Analyst · 2021Review
- Determination of best Raman spectroscopy spatial offsets for transcutaneous bone quality assessments in human hands.Biomedical optics express · 2021Article
- Improved prediction of femoral fracture toughness in mice by combining standard medical imaging with Raman spectroscopy.Journal of biomechanics · 2021Article
- Spatially offset Raman spectroscopy for biomedical applications.Chemical Society reviews · 2021Review
- Soft-tissue spectral subtraction improves transcutaneous Raman estimates of murine bone strength in vivo.Journal of biophotonics · 2020Article
- Assessing matrix quality by Raman spectroscopy helps predict fracture toughness of human cortical bone.Scientific reports · 2019Article
- Spatially offset Raman spectroscopy forBiomedical optics express · 2018Article
- Sensitivity of spatially offset Raman spectroscopy (SORS) to subcortical bone tissue.Journal of biophotonics · 2017Article
- Raman Plus X: Biomedical Applications of Multimodal Raman Spectroscopy.Sensors (Basel, Switzerland) · 2017Review
- Co-localized confocal Raman spectroscopy and optical coherence tomography (CRS-OCT) for depth-resolved analyte detection in tissue.Biomedical optics express · 2015Article
- Contributions of Raman spectroscopy to the understanding of bone strength.BoneKEy reports · 2015Review
- Do laser/LED phototherapies influence the outcome of the repair of surgical bone defects grafted with biphasic synthetic microgranular HA + β-tricalcium phosphate? A Raman spectroscopy study.Lasers in medical science · 2014Article
- Sensitivity of coded aperture Raman spectroscopy to analytes beneath turbid biological tissue and tissue-simulating phantoms.Journal of biomedical optics · 2014Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Clinical diagnoses of bone health and fracture risk typically rely on measurements of bone density or structure, but the strength of a bone is also dependent on its chemical composition. Raman spectroscopy has been used extensively in ex vivo studies to measure the chemical composition of bone. Recently, spatially offset Raman spectroscopy (SORS) has been utilized to measure bone transcutaneously. Although the results are promising, further advancements are necessary to make noninvasive, in vivo measurements of bone with SORS that are of sufficient quality to generate accurate predictions of fracture risk. In order to separate the signals from bone and soft tissue that contribute to a transcutaneous measurement, we developed an overconstrained extraction algorithm that is based on fitting with spectral libraries. This approach allows for accurate spectral unmixing despite the fact that similar chemical components (e.g., type I collagen) are present in both bone and soft tissue. The algorithm was utilized to transcutaneously detect biochemical differences in the tibiae of wild-type mice between 1 and 7 months of age and between the tibiae of wild-type mice and a mouse model of osteogenesis imperfecta. These results represent the first diagnostically sensitive, transcutaneous measurements of bone using SORS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.