SynthesisNature genetics2013
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.
Open access · hybridAbstract readMeta-Analysis
In one paragraph
Synthesis in Nature genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 125 papers, 12 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
125citing papers in PubMed, 12 pooled it
17.4field-weighted citation impact, top 1% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
125 citing papers in PubMed, 12 syntheses or guidelines pooled it, 253 citations in OpenAlex.
- Skin barrier-related genes in childhood atopic dermatitis, asthma, and allergy: A systematic review and meta-analysis.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2026Pooled it
- Skin care interventions in infants for preventing eczema and food allergy.The Cochrane database of systematic reviews · 2022Pooled it
- Discerning asthma endotypes through comorbidity mapping.Nature communications · 2022Pooled it
- Exploring polygenic contributors to subgroups of comorbid conditions in autism spectrum disorder.Scientific reports · 2022Pooled it
- Associations of HLA genotypes with antithyroid drug-induced agranulocytosis: A systematic review and meta-analysis of pharmacogenomics studies.British journal of clinical pharmacology · 2019Pooled it
- GWAS on longitudinal growth traits reveals different genetic factors influencing infant, child, and adult BMI.Science advances · 2019Pooled it
- Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.Nature genetics · 2018Pooled it
- Pooled it
- Genome-wide meta-analysis identifies multiple novel associations and ethnic heterogeneity of psoriasis susceptibility.Nature communications · 2015Pooled it
- Genome-wide association study identifies peanut allergy-specific loci and evidence of epigenetic mediation in US children.Nature communications · 2015Pooled it
- Fine mapping of the celiac disease-associated LPP locus reveals a potential functional variant.Human molecular genetics · 2014Pooled it
- A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.Nature genetics · 2013Pooled it
- Association of STAT6 gene variants with food allergy diagnosed by double-blind placebo-controlled food challenges.Allergy · 2018Trial
- Trial
- Update on the genetics of allergic diseases.The Journal of allergy and clinical immunology · 2025Review
- Targeting alarmins in asthma: From bench to clinic.The Journal of allergy and clinical immunology · 2025Review
- The Role of TLRs in Obesity and Its Related Metabolic Disorders.International journal of molecular sciences · 2025Review
- Multi-omics in Allergic Rhinitis: Mechanism Dissection and Precision Medicine.Clinical reviews in allergy & immunology · 2025Review
- Improvement of glucocorticoid sensitivity and attenuation of pulmonary allergic reactions by exogenous supplementation with betaine in HDM and LPS-induced allergic mouse model.Clinical and translational allergy · 2025Article
- Identifying patients at risk of anaphylaxis.The World Allergy Organization journal · 2024Review
65 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
67 authors at 20 institutions in 9 countries.
Klaus Bønnelykke *COPSAC, Copenhagen Prospective Studies on Asthma in Childhood; Health Sciences, University of Copenhagen & Copenhagen University Hospital, Gentofte, Denmark.
Melanie C Matheson *Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, Australia.
Tune H Pers *Center for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark.
Raquel GranellSchool of Social and Community Medicine, University of Bristol, Bristol, UK.
David P StrachanDivision of Population Health Sciences & Education, St George's, University of London, London, UK.
Alexessander Couto AlvesDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK.
Allan LinnebergResearch Centre for Prevention and Health, Glostrup Hospital, Glostrup, Denmark.
John A CurtinUniversity of Manchester, Manchester Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK.
Nicole M WarringtonSchool of Women's and Infants' Health, The University of Western Australia, Crawley, Australia.
Marie StandlInstitute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Marjan KerkhofDepartment of Epidemiology, Groningen Research Institute for Asthma and COPD (GRIAC), University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Ingileif JonsdottirdeCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland.
Blazenka K BukvicGeneral Hospital "Dr Josip Bencevic" Slavonski Brod, University of Osijek, Osijek, Croatia.
Marika KaakinenInstitute of Health Sciences, University of Oulu, Oulu, Finland.
Patrick SleimannCenter for Applied Genomics, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Gudmar ThorleifssondeCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland.
Unnur ThorsteinsdottirdeCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland.
Katharina SchrammInstitute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
Svetlana BalticLung Institute of WA, University of WA, Perth, Western Australia, Australia.
Eskil Kreiner-MøllerCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood; Health Sciences, University of Copenhagen & Copenhagen University Hospital, Gentofte, Denmark.
Angela SimpsonUniversity of Manchester, Manchester Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK.
Beate St PourcainSchool of Social and Community Medicine, University of Bristol, Bristol, UK.
Lachlan CoinDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK.
Jennie HuiPathWest Laboratory Medicine of Western Australia (WA), Nedlands, Australia.
Eugene H WaltersSchool of Medicine, University of Tasmania, Hobart, Australia.
Carla M T TieslerInstitute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
David L DuffyQueensland Institute of Medical Research, Brisbane, Australia.
Graham JonesSchool of Science and Health, University of Western Sydney, Penrith, Australia.
AAGC
Susan M RingSchool of Social and Community Medicine, University of Bristol, Bristol, UK.
Wendy L McArdleSchool of Social and Community Medicine, University of Bristol, Bristol, UK.
Loren PriceLung Institute of WA, University of WA, Perth, Western Australia, Australia.
Colin F RobertsonRespiratory Medicine, Murdoch Children's Research Institute, Melbourne, Australia.
Juha PekkanenDepartment of Environmental Health, National Institute for Health and Welfare (THL), Kuopio, Finland.
Clara S TangQueensland Institute of Medical Research, Brisbane, Australia.
Elisabeth ThieringInstitute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Grant W MontgomeryQueensland Institute of Medical Research, Brisbane, Australia.
Anna-Liisa HartikainenDepartment of Clinical Sciences, Obstetrics and Gynecology, Institute of Clinical Medicine, University of Oulu, Oulu, Finland.
Shyamali C DharmageCentre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, Australia.
Lise L HusemoenResearch Centre for Prevention and Health, Glostrup Hospital, Glostrup, Denmark.
Christian HerderInstitute for Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
John P KempSchool of Social and Community Medicine, University of Bristol, Bristol, UK.
Paul ElliotDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, UK.
Alan JamesBusselton Population Medical Research Foundation, Sir Charles Gairdner Hospital, Perth, Western Australia, Australia.
Melanie WaldenbergerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Michael J AbramsonDepartment of Epidemiology & Preventive Medicine, Monash University, Melbourne, Australia.
Benjamin P FairfaxWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Julian C KnightWellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
Ramneek GuptaCenter for Biological Sequence Analysis, Technical University of Denmark, Lyngby, Denmark.
Philip J ThompsonLung Institute of WA, University of WA, Perth, Western Australia, Australia.
Patrick HoltTelethon Institute for Child Health Research, The University of Western Australia, Perth, Western Australia, Australia.
Peter SlyQueensland Children's Medical Research Institute, University of Queensland, World Health Organization (WHO) Collaborating Centre for Research on Children's Environmental Health, Australia.
Joel N HirschhornBroad Institute, Cambridge, USA.
Mario BlekicGeneral Hospital "Dr Josip Bencevic" Slavonski Brod, University of Osijek, Osijek, Croatia.
Stephan WeidingerDepartment of Dermatology, Allergology, and Venerology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany.
Hakon HakonarssonCenter for Applied Genomics, The Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.
Kari StefanssondeCODE genetics, Sturlugata 8, 101 Reykjavik, Iceland.
Joachim HeinrichInstitute of Epidemiology I, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg, Germany.
Dirkje S PostmaDepartment of Pulmonology, GRIAC, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Adnan CustovicUniversity of Manchester, Manchester Academic Health Science Centre, University Hospital of South Manchester NHS Foundation Trust, Manchester, UK.
Craig E PennellSchool of Women's and Infants' Health, The University of Western Australia, Crawley, Australia.
Marjo-Riitta JarvelinInstitute of Health Sciences, University of Oulu, Oulu, Finland.
Gerard H KoppelmanDepartment of Pediatric Pulmonology and Pediatric Allergology , Beatrix Children's Hospital, GRIAC, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Nicholas TimpsonSchool of Social and Community Medicine, University of Bristol, Bristol, UK.
Manuel A FerreiraQueensland Institute of Medical Research, Brisbane, Australia.
Hans BisgaardCOPSAC, Copenhagen Prospective Studies on Asthma in Childhood; Health Sciences, University of Copenhagen & Copenhagen University Hospital, Gentofte, Denmark.
A John HendersonSchool of Social and Community Medicine, University of Bristol, Bristol, UK.
University of Western Australia · AUHelmholtz Zentrum München · DEUniversity of Bristol · GBQIMR Berghofer Medical Research Institute · AUdeCODE Genetics (Iceland) · ISImperial College London · GBBoston University · USCopenhagen Prospective Studies on Asthma in Childhood · DKFinnish Institute for Health and Welfare · FIGlostrup Hospital · DKUniversity of Groningen · NLUniversity of Manchester · GBUniversity of Melbourne · AUUniversity of Osijek · HRUniversity of Oulu · FICentre for Human Genetics · GBChildren's Hospital of Philadelphia · USChildren's Medical Research Institute · AUGentofte Hospital · DKHeinrich Heine University Düsseldorf · DE
Funding
Medical Research Council G0601361Medical Research Council G0801056Medical Research Council G1001799Medical Research Council G9815508Medical Research Council MC_PC_15018Medical Research Council MC_UU_12013/3Medical Research Council MR/K002449/1Wellcome Trust 090532Wellcome Trust 092731
Abstract
Allergen-specific immunoglobulin E (present in allergic sensitization) has a central role in the pathogenesis of allergic disease. We performed the first large-scale genome-wide association study (GWAS) of allergic sensitization in 5,789 affected individuals and 10,056 controls and followed up the top SNP at each of 26 loci in 6,114 affected individuals and 9,920 controls. We increased the number of susceptibility loci with genome-wide significant association with allergic sensitization from three to ten, including SNPs in or near TLR6, C11orf30, STAT6, SLC25A46, HLA-DQB1, IL1RL1, LPP, MYC, IL2 and HLA-B. All the top SNPs were associated with allergic symptoms in an independent study. Risk-associated variants at these ten loci were estimated to account for at least 25% of allergic sensitization and allergic rhinitis. Understanding the molecular mechanisms underlying these associations may provide new insights into the etiology of allergic disease.
Indexed as
Genetic LociGenome-Wide Association StudyAllelesComputational BiologyGene Regulatory NetworksGenomicsHumansHypersensitivityPhenotypePolymorphism, Single NucleotideQuantitative Trait LociSignal Transduction
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