ArticleHypertension (Dallas, Tex. : 1979)2013
Female-specific hypertension loci on rat chromosome 13.
Article in Hypertension (Dallas, Tex. : 1979), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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12 citing papers in PubMed, 20 citations in OpenAlex.
- Article
- Mapping genetic modifiers of radiation-induced cardiotoxicity to rat chromosome 3.American journal of physiology. Heart and circulatory physiology · 2019Article
- High-fat diet-induced hypertension is associated with a proinflammatory T cell profile in male and female Dahl salt-sensitive rats.American journal of physiology. Heart and circulatory physiology · 2018Article
- The Gender Impact on Morphogenetic Variability in Coronary Artery Disease: A Preliminary Study.Journal of clinical medicine · 2018Article
- Host genetic modifiers of nonproductive angiogenesis inhibit breast cancer.Breast cancer research and treatment · 2017Article
- Mechanisms of Mas1 Receptor-Mediated Signaling in the Vascular Endothelium.Arteriosclerosis, thrombosis, and vascular biology · 2017Article
- Isolation of a Genomic Region Affecting Most Components of Metabolic Syndrome in a Chromosome-16 Congenic Rat Model.PloS one · 2016Article
- Effects of p67phox on the mitochondrial oxidative state in the kidney of Dahl salt-sensitive rats: optical fluorescence 3-D cryoimaging.American journal of physiology. Renal physiology · 2015Article
- CXM: a new tool for mapping breast cancer risk in the tumor microenvironment.Cancer research · 2014Article
- Vascular dysfunction precedes hypertension associated with a blood pressure locus on rat chromosome 12.American journal of physiology. Heart and circulatory physiology · 2014Article
- Refined mapping of a hypertension susceptibility locus on rat chromosome 12.Hypertension (Dallas, Tex. : 1979) · 2014Article
- Characterization of biological pathways associated with a 1.37 Mbp genomic region protective of hypertension in Dahl S rats.Physiological genomics · 2014Article
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7 authors at 1 institution in 1 country.
Funding
Abstract
A 3.7-Mb region of rat chromosome 13 (45.2-49.0 Mb) affects blood pressure (BP) in females only, indicating the presence of sex-specific BP loci in close proximity to the Renin locus. In the present study, we used a series of Dahl salt-sensitive/Mcwi-13 Brown Norway congenic rat strains to further resolve BP loci within this region. We identified 3 BP loci affecting female rats only, of which the 2 smaller loci (line9BP3 and line9BP4) were functionally characterized by sequence and expression analysis. Compared with SS (SS/HsdMcwiCrl), the presence of a 591-kb region of BN (BN/NHsdMcwi) chromosome 13 (line9BP3) significantly lowered BP by 21 mm Hg on an 8% NaCl diet (153 ± 7 versus 174 ± 5 mm Hg; P<0.001). Unexpectedly, the addition of 23 kb of Brown Norway chromosome 13 (line9BP4) completely erased the female-specific BP protection on 8% NaCl diet, suggesting that BN hypertensive allele(s) reside in this region. The congenic interval of the protective line 9F strain contains 3 genes (Optc, Prelp, and Fmod), and the hypertensive line 9E contains 1 additional gene (Btg2). Sequence analysis of the 2 BP loci revealed a total of 282 intergenic variants, with no coding variants. Analysis of gene expression by quantitative real-time polymerase chain reaction revealed strain- and sex-specific differences in Prelp, Fmod, and Btg2 expression, implicating these as novel candidate genes for female-specific hypertension.
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