Evidence map›Paper›PMID 23817368›Full record

ArticleAntimicrobial agents and chemotherapy2013

Rapid emergence of echinocandin resistance in Candida glabrata resulting in clinical and microbiologic failure.

James S Lewis, Nathan P Wiederhold, Brian L Wickes, Thomas F Patterson, James H Jorgensen

Abstract readCase Reports
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2016
    Guideline
  2. Article
  3. Expression of 1,3-β-glucan synthase subunits inAntimicrobial agents and chemotherapy · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Anti-Candidal Activity of the Parasitic PlantAntibiotics (Basel, Switzerland) · 2021
    Article
  11. Review
  12. Case Report: Echinocandin-ResistanceFrontiers in oncology · 2021
    Article
  13. Pan-Echinocandin-ResistantJournal of fungi (Basel, Switzerland) · 2020
    Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

James S LewisUniversity Health System, Department of Pharmacy, San Antonio, Texas, USA. james.lewis@uhs-sa.com
Nathan P Wiederhold
Brian L Wickes
Thomas F Patterson
James H Jorgensen

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report a case of Candida glabrata candidemia that developed resistance to micafungin within 8 days of initiation of therapy in a patient without previous echinocandin exposure or other known risk factors for clinical or microbiological failure. Pre- and postresistant isolates were confirmed to be isogenic, and sequencing of hot spots known to confer echinocandin resistance revealed a phenylalanine deletion at codon 659 within FKS2.

Indexed as

Antifungal AgentsCandida glabrataCandidemiaDrug Resistance, FungalEchinocandinsFemaleFungal ProteinsGlucosyltransferasesHumansMicrobial Sensitivity TestsMiddle AgedMutationSequence Analysis, DNATime FactorsAntifungal AgentsEchinocandinsFungal ProteinsGlucosyltransferases

Identifiers

PMID23817368
PMCPMC3754289

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.