ArticleThe American journal of tropical medicine and hygiene2013
Community diarrhea incidence before and after rotavirus vaccine introduction in Nicaragua.
Article in The American journal of tropical medicine and hygiene, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Incidence of diarrhoeal disease among children aged less than five years in low- and middle-income countries: a systematic review.Journal of global health · 2025Pooled it
- Efficacy, safety and effectiveness of licensed rotavirus vaccines: a systematic review and meta-analysis for Latin America and the Caribbean.BMC pediatrics · 2017Pooled it
- Complementary Feeding and Diarrhea and Respiratory Infection Among HIV-Exposed Tanzanian Infants.Journal of acquired immune deficiency syndromes (1999) · 2017Trial
- Clinical profile of children under 5 years of age with rotavirus diarrhoea in a hospital setting in Kisangani, DRC, after the introduction of the rotavirus vaccine, a cross-sectional study.BMC pediatrics · 2023Article
- Prevalence of rotavirus infection among children with acute diarrhoea after rotavirus vaccine introduction in Kenya, a hospital cross-sectional study.BMC pediatrics · 2018Article
- Risk Factors for Norovirus Gastroenteritis among Nicaraguan Children.The American journal of tropical medicine and hygiene · 2017Article
- Article
- Childhood diarrhea in high and low hotspot districts of Amhara Region, northwest Ethiopia: a multilevel modeling.Journal of health, population, and nutrition · 2016Observational
- Etiology of childhood diarrhea after rotavirus vaccine introduction: a prospective, population-based study in Nicaragua.The Pediatric infectious disease journal · 2014Article
- Rotavirus vaccines in routine use.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2014Review
- Characterization of enterotoxigenic Escherichia coli strains isolated from Nicaraguan children in hospital, primary care and community settings.Journal of medical microbiology · 2014Article
- Household management of childhood diarrhoea: a population-based study in Nicaragua.Journal of health, population, and nutrition · 2014Article
- Predominance of norovirus and sapovirus in Nicaragua after implementation of universal rotavirus vaccination.PloS one · 2014Article
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Authors and funding
12 authors.
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Abstract
We estimated the incidence of watery diarrhea in the community before and after introduction of the pentavalent rotavirus vaccine in León, Nicaragua. A random sample of households was selected before and after rotavirus vaccine introduction. All children < 5 years of age in selected households were eligible for inclusion. Children were followed every 2 weeks for watery diarrhea episodes. The incidence rate was estimated as numbers of episodes per 100 child-years of exposure time. A mixed effects Poisson regression model was fit to compare incidence rates in the pre-vaccine and vaccine periods. The pre-vaccine cohort (N = 726) experienced 36 episodes per 100 child-years, and the vaccine cohort (N = 826) experienced 25 episodes per 100 child-years. The adjusted incidence rate ratio was 0.60 (95% confidence interval [CI] 0.40, 0.91) during the vaccine period versus the pre-vaccine period, indicating a lower incidence of watery diarrhea in the community during the vaccine period.
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