ArticleInternational journal of obesity (2005)2014
Characterization and predicted role of the microRNA expression profile in amnion from obese pregnant women.
Article in International journal of obesity (2005), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 37 citations in OpenAlex.
- Placental mRNA and miRNA dynamics associated with lipid metabolism pathways in pregnancies affected by obesity.Frontiers in endocrinology · 2025Article
- Nutrition and Developmental Origins of Kidney Disease.Nutrients · 2023Review
- The role of miRNA molecules in the miscarriage process.Biology of reproduction · 2023Article
- The Novel-miR-659/Animals : an open access journal from MDPI · 2022Article
- Trimester-specific plasma exosome microRNA expression profiles in preeclampsia.The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians · 2020Article
- Fetal Membrane Epigenetics.Frontiers in physiology · 2020Review
- Maternal obesity alters C19MC microRNAs expression profile in fetal umbilical cord blood.Nutrition & metabolism · 2020Article
- Transcriptome analysis of miRNA and mRNA in the livers of pigs with highly diverged backfat thickness.Scientific reports · 2019Article
- MicroRNAs as Potential Regulators of Glutathione Peroxidases Expression and Their Role in Obesity and Related Pathologies.International journal of molecular sciences · 2018Review
- MicroRNA expression profiling in placenta and maternal plasma in early pregnancy loss.Molecular medicine reports · 2018Article
- Hypothalamic miR-219 regulates individual metabolic differences in response to diet-induced weight cycling.Molecular metabolism · 2018Article
- Gene-Diet Interactions in Type 2 Diabetes: The Chicken and Egg Debate.International journal of molecular sciences · 2017Review
- A Review of the Impact of Maternal Obesity on the Cognitive Function and Mental Health of the Offspring.International journal of molecular sciences · 2017Review
- Proteome analysis of human amniotic mesenchymal stem cells (hA-MSCs) reveals impaired antioxidant ability, cytoskeleton and metabolic functionality in maternal obesity.Scientific reports · 2016Article
- MicroRNAs as regulators of metabolic disease: pathophysiologic significance and emerging role as biomarkers and therapeutics.International journal of obesity (2005) · 2016Review
- Effects of Maternal Obesity on Fetal Programming: Molecular Approaches.Cold Spring Harbor perspectives in medicine · 2015Review
- Maternal pre-pregnancy body mass index and circulating microRNAs in pregnancy.Obesity research & clinical practiceArticle
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maternal obesity and nutrient excess in utero increase the risk of future metabolic diseases. The mechanisms underlying this process are poorly understood, but probably include genetic, epigenetic alterations and changes in fetal nutrient supply. We have studied the microRNA (miRNA) expression profile in amnion from obese and control women at delivery to investigate if a specific miRNA signature is associated with obesity. The expression profile of 365 human miRNAs was evaluated with the TaqMan Array in amnion from 10 obese and 5 control (prepregnancy body mass index (BMI) >30 and <25 kg m(-2), respectively) women at delivery. Target genes and miRNA-regulated pathways were predicted by bioinformatics. Anthropometric and biochemical parameters were also measured in mothers and newborns. Seven miRNAs were expressed only in obese women (miR-422b, miR-219, miR-575, miR-523, miR-579, miR-618 and miR-659), whereas 13 miRNAs were expressed at a higher level and 12 miRNAs at a lower level in obese women than in controls. MicroRNAs significantly downregulated the neurotrophin, cancer/ErbB, mammalian target of rapamycin, insulin, adipocytokine, actin cytoskeleton and mitogen-activated protein kinase signaling pathways. In conclusion, we show that the miRNA profile is altered in amnion during obesity and hypothesize that this could affect pathways important for placental growth and function, thereby contributing to an increase in the newborn's risk of future metabolic diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.