ReviewGenome research2013
Understanding the regulatory and transcriptional complexity of the genome through structure.
Review in Genome research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed.
- Horizontal Transfer of Malignant Traits and the Involvement of Extracellular Vesicles in Metastasis.Cells · 2023Review
- Self-empowerment of life through RNA networks, cells and viruses.F1000Research · 2023Review
- Extended intergenic DNA contributes to neuron-specific expression of neighboring genes in the mammalian nervous system.Nature communications · 2022Article
- Oscillatory Behaviors of microRNA Networks: Emerging Roles in Retinal Development.Frontiers in cell and developmental biology · 2022Review
- Predicting transcription factor binding in single cells through deep learning.Science advances · 2020Article
- Linear and circular PVT1 in hematological malignancies and immune response: two faces of the same coin.Molecular cancer · 2020Review
- lncRNA PSORS1C3 is regulated by glucocorticoids and fine-tunes OCT4 expression in non-pluripotent cells.Scientific reports · 2019Article
- Noncoding RNAs in cardiovascular diseases.Current opinion in cardiology · 2019Review
- Non-Coding RNAs in Retinoblastoma.Frontiers in genetics · 2019Review
- Epigenetic Regulation Of Axon Regeneration and Glial Activation in Injury Responses.Frontiers in genetics · 2019Review
- Revealing Gene Function and Transcription Relationship by Reconstructing Gene-Level Chromatin Interaction.Computational and structural biotechnology journal · 2019Article
- Gene editing in the context of an increasingly complex genome.BMC genomics · 2018Review
- Article
- Exosomal lncRNAs as new players in cell-to-cell communication.Translational cancer research · 2018Article
- Epigenetic mechanisms underlying nervous system diseases.Handbook of clinical neurology · 2018Review
- The Long Noncoding RNA HOTAIR in Breast Cancer: Does Autophagy Play a Role?International journal of molecular sciences · 2017Review
- MAPK-triggered chromatin reprogramming by histone deacetylase in plant innate immunity.Genome biology · 2017Article
- The Th2 gene cluster unraveled: role of RHS6.Allergy · 2017Article
- An Alternative Nested Reading Frame May Participate in the Stress-Dependent Expression of a Plant Gene.Frontiers in plant science · 2017Article
- Unveiling the Impact of the Genomic Architecture on the Evolution of Vertebrate microRNAs.Frontiers in genetics · 2017Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An expansive functionality and complexity has been ascribed to the majority of the human genome that was unanticipated at the outset of the draft sequence and assembly a decade ago. We are now faced with the challenge of integrating and interpreting this complexity in order to achieve a coherent view of genome biology. We argue that the linear representation of the genome exacerbates this complexity and an understanding of its three-dimensional structure is central to interpreting the regulatory and transcriptional architecture of the genome. Chromatin conformation capture techniques and high-resolution microscopy have afforded an emergent global view of genome structure within the nucleus. Chromosomes fold into complex, territorialized three-dimensional domains in concert with specialized subnuclear bodies that harbor concentrations of transcription and splicing machinery. The signature of these folds is retained within the layered regulatory landscapes annotated by chromatin immunoprecipitation, and we propose that genome contacts are reflected in the organization and expression of interweaved networks of overlapping coding and noncoding transcripts. This pervasive impact of genome structure favors a preeminent role for the nucleoskeleton and RNA in regulating gene expression by organizing these folds and contacts. Accordingly, we propose that the local and global three-dimensional structure of the genome provides a consistent, integrated, and intuitive framework for interpreting and understanding the regulatory and transcriptional complexity of the human genome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.