ArticleThe Journal of cell biology2013
Probing the depths of cellular senescence.
Article in The Journal of cell biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed.
- Senotypes define the diverse landscape of senescent cells.Nature aging · 2026Review
- Hypoxia Preserves Chromatin Integrity and Delays Cellular Senescence through Epigenetic Regulation.Biomolecules & therapeutics · 2026Review
- Hypoxia increases methylated histones to prevent histone clipping and heterochromatin redistribution during Raf-induced senescence.Nucleic acids research · 2025Article
- Quiescence-Origin Senescence: A New Paradigm in Cellular Aging.Biomedicines · 2024Article
- Multi-omics and single cell characterization of cancer immunosenescence landscape.Scientific data · 2024Article
- Modeling the Depth of Cellular Dormancy from RNA-Sequencing Data.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Understanding cellular senescence: pathways involved, therapeutics and longevity aiding.Cell cycle (Georgetown, Tex.) · 2023Review
- Brain cellular senescence in mouse models of Alzheimer's disease.GeroScience · 2022Article
- The metabolic roots of senescence: mechanisms and opportunities for intervention.Nature metabolism · 2021Review
- Using a new HSPC senescence model in vitro to explore the mechanism of cellular memory in aging HSPCs.Stem cell research & therapy · 2021Article
- Review
- AtFAHD1a: A New Player Influencing Seed Longevity and Dormancy in Arabidopsis?International journal of molecular sciences · 2021Article
- From Development to Aging: The Path to Cellular Senescence.Antioxidants & redox signaling · 2021Review
- Non-canonical ATM/MRN activities temporally define the senescence secretory program.EMBO reports · 2020Article
- Article
- Transcriptome signature of cellular senescence.Nucleic acids research · 2019Article
- Short-term gain, long-term pain: the senescence life cycle and cancer.Genes & development · 2019Review
- Replication stress-induced endogenous DNA damage drives cellular senescence induced by a sub-lethal oxidative stress.Nucleic acids research · 2017Article
- Nucleolar aggresomes mediate release of pericentric heterochromatin and nuclear destruction of genotoxically treated cancer cells.Nucleus (Austin, Tex.) · 2017Article
- Autocrine IL-6 mediates pituitary tumor senescence.Oncotarget · 2017Article
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cellular senescence is a state of irreversible cell cycle arrest that has been documented to both suppress cancer and promote aging. Although not well understood, extensive nuclear changes, including the remodeling of chromatin, take place as cells become senescent. In this issue, Ivanov et al. (2013. J. Cell Biol. http://dx.doi.org/jcb.201212110) report that chromatin fragments are released from the nuclei of senescent cells and are subsequently targeted for processing through the autophagy/lysosomal pathway.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.