ArticleInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases2014
Differing lifestyles of Staphylococcus epidermidis as revealed through Bayesian clustering of multilocus sequence types.
Article in Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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24 citing papers in PubMed, 39 citations in OpenAlex.
- Strain-level genomic analysis ofMicrobiology spectrum · 2026Article
- Global distribution, antimicrobial resistance, and virulence factors of Staphylococcus epidermidis revealed through population genomics.BMC genomics · 2026Article
- Of Commensals and Opportunists: Genomics of Coagulase-Negative Staphylococci During Sequential Ear and Eye Infections in a Healthy Adult.MicrobiologyOpen · 2026Article
- Screen for signatures of positive selection in the core genome ofMicrobial genomics · 2026Article
- Genomic and phenotypic characterization of staphylococci isolated from the skin of non-human primates.Microbiology (Reading, England) · 2025Article
- Cryptic susceptibility to penicillin/β-lactamase inhibitor combinations in emerging multidrug-resistant, hospital-adapted Staphylococcus epidermidis lineages.Nature communications · 2023Article
- Improved Genomic Prediction of Staphylococcus epidermidis Isolation Sources with a Novel Polygenic Score.Journal of clinical microbiology · 2023Article
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- High-Resolution Typing ofJournal of clinical microbiology · 2021Article
- Virulence Factors in Coagulase-Negative Staphylococci.Pathogens (Basel, Switzerland) · 2021Review
- Plasmid-Chromosome Crosstalk inFrontiers in cellular and infection microbiology · 2021Article
- Vancomycin Heteroresistance and Clinical Outcomes in Bloodstream Infections Caused by Coagulase-Negative Staphylococci.Antimicrobial agents and chemotherapy · 2020Article
- Coagulase-Negative Staphylococci Contained in Gut Microbiota as a Primary Source of Sepsis in Low- and Very Low Birth Weight Neonates.Journal of clinical medicine · 2020Article
- Article
- Genetic Diversity of Composite Enterotoxigenic Staphylococcus epidermidis Pathogenicity Islands.Genome biology and evolution · 2019Article
- Clonally Diverse Methicillin and Multidrug Resistant Coagulase Negative Staphylococci Are Ubiquitous and Pose Transfer Ability Between Pets and Their Owners.Frontiers in microbiology · 2019Article
- Global spread of three multidrug-resistant lineages of Staphylococcus epidermidis.Nature microbiology · 2018Article
- Significant Enrichment and Diversity of the Staphylococcal Arginine Catabolic Mobile Element ACME inFrontiers in microbiology · 2018Article
- Colonization of patients, healthcare workers, and the environment with healthcare-associated Staphylococcus epidermidis genotypes in an intensive care unit: a prospective observational cohort study.BMC infectious diseases · 2016Observational
- Molecular Epidemiology of a Vancomycin-Intermediate Heteroresistant Staphylococcus epidermidis Outbreak in a Neonatal Intensive Care Unit.Antimicrobial agents and chemotherapy · 2016Article
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Staphylococcus epidermidis is part of the normal bacterial flora of human skin and a leading cause of infections associated with indwelling medical devices. Previous phylogenetic analyses of subgenomic data have been unable to distinguish between S. epidermidis strains with nosocomial or commensal lifestyles, despite the identification of specific phenotypes and accessory genes that may contribute to such lifestyles. To attempt to better define the population structure of this species, the international S. epidermidis multilocus sequence typing database was analyzed with the Bayesian clustering programs STRUCTURE and BAPS. A total of six genetic clusters (GCs) were identified. A local population of S. epidermidis from clinical specimens was classified according to these six GCs, and further characterized for antibiotic susceptibilities, biofilm, and various genetic markers. GC5 was abundant and significantly enriched for isolates that were resistant to four classes of antibiotics, high biofilm production, and positive for the virulence markers icaA, IS256, and sesD/bhp, indicating its potential clinical relevance. In contrast, GC2 was rare and contained the only isolates positive for the putative commensal marker, fdh. GC1 and GC6 were abundant but not significantly associated with any of the examined characteristics, except for sesF/aap and GC6. GC3 was rare and identified as a potential genetic sink that received, but did not donate, core genetic material from other GCs. In conclusion, population genetics analyses were essential for identifying clusters of strains that may differ in their adaptation to nosocomial or commensal lifestyles. These results provide a new, population genetics framework for studying S. epidermidis.
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