ArticleEnvironmental health : a global access science source2013
A cross-sectional study of the impact of blood selenium on blood and urinary arsenic concentrations in Bangladesh.
Article in Environmental health : a global access science source, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- Biomonitoring of nutritional and toxic elements in raw and cooked rice in the Health Effects of Arsenic Longitudinal Study, Bangladesh.Ecotoxicology and environmental safety · 2026Article
- Returning personal genetic information on susceptibility to arsenic toxicity to research participants in Bangladesh.Environmental research · 2024Article
- Validation of blood arsenic and manganese assessment from archived clotted erythrocyte fraction in an urban cohort of mother-child dyads.The Science of the total environment · 2022Article
- Article
- Influences on tidal channel and aquaculture shrimp pond water chemical composition in Southwest Bangladesh.Geochemical transactions · 2021Article
- Relationships among Inorganic Arsenic, Nutritional Status CpG Methylation and microRNAs: A Review of the Literature.Epigenetics insights · 2021Review
- Chronic kidney disease of unknown aetiology in Sri Lanka and the exposure to environmental chemicals: a review of literature.Environmental geochemistry and health · 2019Review
- Environmental Toxicant Exposures and Type 2 Diabetes Mellitus: Two Interrelated Public Health Problems on the Rise.Current opinion in toxicology · 2018Article
- The Metal Neurotoxins: An Important Role in Current Human Neural Epidemics?International journal of environmental research and public health · 2017Review
- Dietary micronutrient intake and its relationship with arsenic metabolism in Mexican women.Environmental research · 2016Article
- Arsenic Metabolism in Children Differs From That in Adults.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
- Arsenic and Environmental Health: State of the Science and Future Research Opportunities.Environmental health perspectives · 2016Review
- Direct Quantification of Rare Earth Elements Concentrations in Urine of Workers Manufacturing Cerium, Lanthanum Oxide Ultrafine and Nanoparticles by a Developed and Validated ICP-MS.International journal of environmental research and public health · 2016Article
- Association between lifetime exposure to inorganic arsenic in drinking water and coronary heart disease in Colorado residents.Environmental health perspectives · 2015Article
- Importance of Arsenic and pesticides in epidemic chronic kidney disease in Sri Lanka.BMC nephrology · 2014Article
- The Effects of Arsenic Exposure on Neurological and Cognitive Dysfunction in Human and Rodent Studies: A Review.Current environmental health reports · 2014Review
- Friend or foe? The current epidemiologic evidence on selenium and human cancer risk.Journal of environmental science and health. Part C, Environmental carcinogenesis & ecotoxicology reviews · 2013Review
- Gestational Arsenic Trioxide Exposure Acts as a Developing Neuroendocrine-Disruptor by Downregulating Nrf2/PPARγ and Upregulating Caspase-3/NF-ĸB/Cox2/BAX/iNOS/ROS.Dose-response : a publication of International Hormesis SocietyArticle
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundArsenic can naturally occur in the groundwater without an anthropogenic source of contamination. In Bangladesh over 50 million people are exposed to naturally occurring arsenic concentrations exceeding the World Health Organization's guideline of 10 μg/L. Selenium and arsenic have been shown to facilitate the excretion of each other in bile. Recent evidence suggests that selenium may play a role in arsenic elimination by forming a selenium-arsenic conjugate in the liver before excretion into the bile.
methodsA cross-sectional study of 1601 adults and 287 children was conducted to assess the relationship between blood selenium and urinary and blood arsenic in a study population residing in a moderately arsenic-contaminated rural area in Bangladesh.
resultsThe results of this study indicate a statistically significant inverse relationship between blood selenium and urinary arsenic concentrations in both adult and pediatric populations in rural Bangladesh after adjustment for age, sex, Body Mass Index, plasma folate and B12 (in children), and ever smoking and current betel nut use (in adults). In addition, there appears to be a statistically significant inverse relationship between blood selenium and blood arsenic in children.
conclusionsOur results suggest that selenium is inversely associated with biomarkers of arsenic burden in both adults and children. These findings support the hypothesis that Se facilitates the biliary elimination of As, possibly via the putative formation of a Se-As conjugate using a glutathione complex. However, laboratory based studies are needed to provide further evidence to elucidate the presence of Se-As conjugate and its role in arsenic elimination in humans.
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