ArticleBMC cancer2013
Defect in recruiting effector memory CD8+ T-cells in malignant pleural effusions compared to normal pleural fluid.
Article in BMC cancer, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 46 citations in OpenAlex.
- Changes in the immune index before and after surgery in urinary malignancy patients with AIDS.Scientific reports · 2025Article
- Immune modulation in malignant pleural effusion: from microenvironment to therapeutic implications.Cancer cell international · 2024Review
- Immunological characterization of pleural effusions in pediatric patients.Frontiers in immunology · 2024Article
- Prognostic role of immune microenvironment in pleural metastases from breast and lung adenocarcinomas.Annals of translational medicine · 2022Article
- Higher CD4/CD8 ratio of pleural effusion predicts better survival for lung cancer patients receiving immune checkpoint inhibitors.Scientific reports · 2021Article
- Malignant Pleural Effusions-A Window Into Local Anti-Tumor T Cell Immunity?Frontiers in oncology · 2021Review
- Characteristics of Malignant Pleural Effusion Resident CD8International journal of molecular sciences · 2020Article
- Clinical efficacy of intra-cavitary infusions of autologous dendritic cell/cytokine-induced killer cell products for the treatment of refractory malignant pleural effusions and ascites.American journal of translational research · 2020Article
- The NAD-dependent deacetylase SIRT2 regulates T cell differentiation involved in tumor immune response.International journal of biological sciences · 2020Article
- Migrated T lymphocytes into malignant pleural effusions: an indicator of good prognosis in lung adenocarcinoma patients.Scientific reports · 2019Article
- Cytotoxic Natural Killer Subpopulations as a Prognostic Factor of Malignant Pleural Effusion.Lung · 2019Observational
- The Immune Microenvironment in Mesothelioma: Mechanisms of Resistance to Immunotherapy.Frontiers in oncology · 2019Review
- Tumour associated lymphocytes in the pleural effusions of patients with mesothelioma express high levels of inhibitory receptors.BMC research notes · 2018Article
- The era of immunogenomics/immunopharmacogenomics.Journal of human genetics · 2018Review
- Memory CD4Cellular oncology (Dordrecht, Netherlands) · 2018Article
- Abundant expression of TIM-3, LAG-3, PD-1 and PD-L1 as immunotherapy checkpoint targets in effusions of mesothelioma patients.Oncotarget · 2017Article
- Interleukin-2 reverses CD8(+) T cell exhaustion in clinical malignant pleural effusion of lung cancer.Clinical and experimental immunology · 2016Article
- Malignant pleural effusion: from bench to bedside.European respiratory review : an official journal of the European Respiratory Society · 2016Review
- Analysis of Lymphocyte Immunological Reactivity in Patients with Pleural Effusions of Different Aetiology.Open access Macedonian journal of medical sciences · 2016Article
- Review
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Authors and funding
11 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMalignant pleural effusions (MPE) are a common and fatal complication in cancers including lung or breast cancers, or malignant pleural mesothelioma (MPM). MPE animal models and immunotherapy trials in MPM patients previously suggested defects of the cellular immunity in MPE. However only few observational studies of the immune response were done in MPM patients, using questionable control groups (transudate…).
methodsWe compared T cell populations evaluated by flow cytometry from blood and pleural effusion of untreated patients with MPM (n = 58), pleural metastasis of adenocarcinoma (n = 30) or with benign pleural lesions associated with asbestos exposure (n = 23). Blood and pleural fluid were also obtained from healthy subjects, providing normal values for T cell populations.
resultsBlood CD4+ or CD8+ T cells percentages were similar in all groups of patients or healthy subjects. Whereas pleural fluid from healthy controls contained mainly CD8+ T cells, benign or malignant pleural effusions included mainly CD4+ T cells. Effector memory T cells were the main T cell subpopulation in pleural fluid from healthy subjects. In contrast, there was a striking and selective recruitment of central memory CD4+ T cells in MPE, but not of effector cells CD8+ T cells or NK cells in the pleural fluid as one would expect in order to obtain an efficient immune response.
conclusionsComparing for the first time MPE to pleural fluid from healthy subjects, we found a local defect in recruiting effector CD8+ T cells, which may be involved in the escape of tumor cells from immune response. Further studies are needed to characterize which subtypes of effector CD8+ T cells are involved, opening prospects for cell therapy in MPE and MPM.
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