Trial reportAmerican heart journal2013
Adverse outcomes among women presenting with signs and symptoms of ischemia and no obstructive coronary artery disease: findings from the National Heart, Lung, and Blood Institute-sponsored Women's Ischemia Syndrome Evaluation (WISE) angiographic core laboratory.
Trial report in American heart journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 114 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
114 citing papers in PubMed, 3 syntheses or guidelines pooled it, 188 citations in OpenAlex.
- Understanding Myocardial Infarction with Non-Obstructive Coronary Arteries (MINOCA): a comprehensive meta-analysis of clinical characteristics, management, and prognosis compared to MI with the Obstructive Coronary Artery (MIOCA).BMC cardiovascular disorders · 2025Pooled it
- Shedding Light on Treatment Options for Coronary Vasomotor Disorders: A Systematic Review.Cardiovascular drugs and therapy · 2024Pooled it
- Evaluation of non-invasive imaging parameters in coronary microvascular disease: a systematic review.BMC medical imaging · 2021Pooled it
- Sex Differences in Revascularization, Treatment Goals, and Outcomes of Patients With Chronic Coronary Disease: Insights From the ISCHEMIA Trial.Journal of the American Heart Association · 2024Trial
- Late sodium channel blockade improves angina and myocardial perfusion in patients with severe coronary microvascular dysfunction: Women's Ischemia Syndrome Evaluation-Coronary Vascular Dysfunction ancillary study.International journal of cardiology · 2019Trial
- Sex Differences in Functional and CT Angiography Testing in Patients With Suspected Coronary Artery Disease.Journal of the American College of Cardiology · 2016Trial
- Stable angina in young women.European heart journal · 2026Review
- Artificial intelligence-enabled plaque characterization from coronary computed tomography establishes basis of angina in women with nonobstructive atherosclerosis.Communications medicine · 2026Article
- Persistent chest pain trends at 3 years in women with INOCA vs. obstructive CAD: results from the NHLBI-sponsored women's ischemia syndrome evaluation (WISE).European heart journal. Quality of care & clinical outcomes · 2026Article
- Transient cavity dilatation during supine exercise bicycle stress testing: mechanistic insights.Echo research and practice · 2026Article
- 2026 Focused Update of the Saudi Heart Association Guidelines on Best Practices in the Management of Chronic Coronary Syndromes.Journal of the Saudi Heart Association · 2026Article
- Symptom experience of women with ischemia and no obstructive coronary artery disease: A mixed-methods approach.American heart journal plus : cardiology research and practice · 2026Article
- Article
- Is MINOCA Syndrome Causing Fatal Left Ventricular Aneurysms Less Innocent than It Appears?Balkan medical journal · 2025Article
- Intracoronary acetylcholine for vasospasm provocation in women with ischemia and no obstructive coronary artery disease.American heart journal plus : cardiology research and practice · 2025Article
- Impact of Diabetes Duration on Major Adverse Cardiac Events in Patients with Non-Obstructive Coronary Artery Disease.Journal of clinical medicine · 2025Article
- QUIET WARRIOR - Rationale and design: An ancillary study to the Women's IschemiA TRial to Reduce Events in Nonobstructive CAD (WARRIOR).American heart journal plus : cardiology research and practice · 2025Article
- ANOCA, INOCA, MINOCA: The New Frontier of Coronary Syndromes.Journal of cardiovascular development and disease · 2025Review
- Adherence to secondary preventive treatment following myocardial infarction with and without obstructive coronary artery disease.PloS one · 2025Observational
- Unveiling the Longitudinal Journey: 3-Year Follow-up of Women with MINOCA and INOCA in a Specialized Heart Centre.CJC open · 2024Article
54 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundWomen presenting with signs and symptoms of myocardial ischemia frequently have no or nonobstructive coronary artery disease (CAD).
objectiveThis study aimed to investigate the associations between angiographic measures and longer-term clinical outcomes among women with signs and symptoms of ischemia referred for coronary angiography.
methodsA prospective cohort analysis of women referred for coronary angiography and enrolled in the National Heart, Lung, and Blood Institute-sponsored WISE was performed. An angiographic severity score was prospectively developed, assigning points for any stenosis weighted by stenosis severity, location, and collaterals and was then tested for prediction for adverse outcome in 917 women, over a median of 9.3 years.
settingThe study was conducted in referral centers. PATIENTS: Women with signs and/or symptoms of myocardial ischemia referred for coronary angiography were consecutively consented and enrolled in a prospective study.
main outcome measuresMain outcomes included first occurrence of cardiovascular death or nonfatal myocardial infarction. Hospitalization for angina was a secondary outcome.
resultsCardiovascular death or myocardial infarction at 10 years occurred in 6.7%, 12.8%, and 25.9% of women with no, nonobstructive, and obstructive CAD (P < .0001), respectively. Cumulative 10-year cardiovascular death or myocardial infarction rates showed progressive, near-linear increases for each WISE CAD severity score range of 5, 5.1 to 10, 10.1 to 20, 20.1 to 50, and >50. The optimal threshold in the WISE severity score classifications for predicting cardiovascular mortality was >10 (eg, 5.0-10 vs 10.1-89), with both a sensitivity and specificity of 0.64 and an area under the curve of 0.64 (P = .02, 95% CI 0.59-0.68).
conclusionsAmong women with signs and symptoms of ischemia, nonobstructive CAD is common and associated with adverse outcomes over the longer term. The new WISE angiographic score appears to be useful for risk prediction in this population.
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What OpenQuestion holds
Registered trials
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