ArticleThe journal of physical chemistry. B2013
Kinetic modeling of the X-ray-induced damage to a metalloprotein.
Article in The journal of physical chemistry. B, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Time-resolved Mn KThe Journal of biological chemistry · 2026Article
- X-ray Emission Spectroscopy of Single Protein Crystals Yields Insights into Heme Enzyme Intermediates.The journal of physical chemistry letters · 2023Article
- Ionizing Radiation: Effective Physical Agents for Economic Crop Seed Priming and the Underlying Physiological Mechanisms.International journal of molecular sciences · 2022Review
- X-ray Emission Spectroscopy at X-ray Free Electron Lasers: Limits to Observation of the Classical Spectroscopic Response for Electronic Structure Analysis.The journal of physical chemistry letters · 2019Article
- X-ray-induced sample damage at the Mn L-edge: a case study for soft X-ray spectroscopy of transition metal complexes in solution.Physical chemistry chemical physics : PCCP · 2018Article
- Pink-beam serial crystallography.Nature communications · 2017Article
- High-density grids for efficient data collection from multiple crystals.Acta crystallographica. Section D, Structural biology · 2016Article
- Article
- From protein structure to function via single crystal optical spectroscopy.Frontiers in molecular biosciences · 2015Review
- Goniometer-based femtosecond crystallography with X-ray free electron lasers.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Serial time-resolved crystallography of photosystem II using a femtosecond X-ray laser.Nature · 2014Article
- Assembly of nonheme Mn/Fe active sites in heterodinuclear metalloproteins.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2014Review
- Diffraction before destruction.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2014Article
- DIY XES - development of an inexpensive, versatile, and easy to fabricate XES analyzer and sample delivery system.X-ray spectrometry : XRSArticle
- Rapid evolution of the Photosystem II electronic structure during water splitting.Physical review. XArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
It is well-known that biological samples undergo X-ray-induced degradation. One of the fastest occurring X-ray-induced processes involves redox modifications (reduction or oxidation) of redox-active cofactors in proteins. Here we analyze room-temperature data on the photoreduction of Mn ions in the oxygen-evolving complex (OEC) of photosystem II, one of the most radiation damage-sensitive proteins and a key constituent of natural photosynthesis in plants, green algae, and cyanobacteria. Time-resolved X-ray emission spectroscopy with wavelength-dispersive detection was used to collect data on the progression of X-ray-induced damage. A kinetic model was developed to fit experimental results, and the rate constant for the reduction of OEC Mn(III) and Mn(IV) ions by solvated electrons was determined. From this model, the possible kinetics of X-ray-induced damage at a variety of experimental conditions, such as different rates of dose deposition as well as different excitation wavelengths, can be inferred. We observed a trend of increasing dosage threshold prior to the onset of X-ray-induced damage with increasing rates of dose deposition. This trend suggests that experimentation with higher rates of dose deposition is beneficial for measurements of biological samples sensitive to radiation damage, particularly at pink beam and X-ray free electron laser sources.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.