ArticleEuropean journal of microbiology & immunology2013
Genomic background-related activation of microglia and reduced β-amyloidosis in a mouse model of Alzheimer's disease.
Article in European journal of microbiology & immunology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- The ABC transporter A7 modulates neuroinflammation via NLRP3 inflammasome in Alzheimer's disease mice.Alzheimer's research & therapy · 2025Article
- Machine Learning-Supported Analyses Improve Quantitative Histological Assessments of Amyloid-β Deposits and Activated Microglia.Journal of Alzheimer's disease : JAD · 2021Article
- Compromised Astrocyte Swelling/Volume Regulation in the Hippocampus of the Triple Transgenic Mouse Model of Alzheimer's Disease.Frontiers in aging neuroscience · 2021Article
- Measurement of cerebral ABCC1 transport activity in wild-type and APP/PS1-21 mice with positron emission tomography.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Detection and Prediction of Mild Cognitive Impairment in Alzheimer's Disease Mice.Journal of Alzheimer's disease : JAD · 2020Article
- The Influence of Murine Genetic Background in Adeno-Associated Virus Transduction of the Mouse Brain.Human gene therapy. Clinical development · 2019Article
- Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice.Acta neuropathologica communications · 2017Article
- Revisiting rodent models: Octodon degus as Alzheimer's disease model?Acta neuropathologica communications · 2016Article
- Sideritis spp. Extracts Enhance Memory and Learning in Alzheimer's β-Amyloidosis Mouse Models and Aged C57Bl/6 Mice.Journal of Alzheimer's disease : JAD · 2016Article
- Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes.Acta neuropathologica communications · 2016Article
- Spinal cord pathology in chronic experimental Toxoplasma gondii infection.European journal of microbiology & immunology · 2014Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Alzheimer's disease (AD) is by far the most common neurodegenerative disease. AD is histologically characterized not only by extracellular senile plaques and vascular deposits consisting of β-amyloid (Aβ) but also by accompanying neuroinflammatory processes involving the brain's microglia. The importance of the microglia is still in controversial discussion, which currently favors a protective function in disease progression. Recent findings by different research groups highlighted the importance of strain-specific and mitochondria-specific genomic variations in mouse models of cerebral β-amyloidosis. Here, we want to summarize our previously presented data and add new results that draw attention towards the consideration of strain-specific genomic alterations in the setting of APP transgenes. We present data from APP-transgenic mice in commonly used C57Bl/6J and FVB/N genomic backgrounds and show a direct influence on the kinetics of Aβ deposition and the activity of resident microglia. Plaque size, plaque deposition rate and the total amount of Aβ are highest in C57Bl/6J mice as compared to the FVB/N genomic background, which can be explained at least partially by a reduced microglia activity towards amyloid deposits in the C57BL/6J strain.
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