ArticleTherapeutic advances in gastroenterology2013
LINX(®) Reflux Management System in chronic gastroesophageal reflux: a novel effective technology for restoring the natural barrier to reflux.
Article in Therapeutic advances in gastroenterology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Systematic review of the introduction and evaluation of magnetic augmentation of the lower oesophageal sphincter for gastro-oesophageal reflux disease.The British journal of surgery · 2020Pooled it
- LINXSurgical endoscopy · 2017Pooled it
- Large-caliber endoscopic balloon dilation in patients with persistent dysphagia after magnetic sphincter augmentation (MSA) is safe and may reduce the need for subsequent dilations and device removal.Surgical endoscopy · 2026Article
- No added risk: national outcomes of magnetic sphincter explant with hiatal hernia repair and fundoplication.Surgical endoscopy · 2026Article
- Magnetic sphincter augmentation for gastroesophageal reflux after sleeve gastrectomy: a prospective study.Surgical endoscopy · 2025Article
- Protocol for the GOLF trial: randomized clinical trial on the LINX management system versus fundoplication for the surgical treatment of gastro-oesophageal reflux disease.The British journal of surgery · 2025Article
- Dumping Syndrome Post Hiatal Hernia Repair With the LINX Sphincter Augmentation Device.Cureus · 2025Article
- Challenges of Revisional Metabolic and Bariatric Surgery: A Comprehensive Guide to Unraveling the Complexities and Solutions of Revisional Bariatric Procedures.Journal of clinical medicine · 2024Review
- Safety of transvenous cardiac defibrillator and magnetic titanium beads system for gastroesophageal reflux disease: a case report.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2023Article
- Removal of the magnetic sphincter augmentation device: an assessment of etiology, clinical presentation, and management.Surgical endoscopy · 2023Article
- The Impact of Magnetic Sphincter Augmentation (MSA) on Esophagogastric Junction (EGJ) and Esophageal Body Physiology and Manometric Characteristics.Annals of surgery · 2023Article
- Feasibility and Efficacy of Magnetic Sphincter Augmentation for the Management of Gastroesophageal Reflux Disease Post-Sleeve Gastrectomy for Obesity.Obesity surgery · 2023Observational
- Ancillary treatment of patients with lung disease due to non-tuberculous mycobacteria: a narrative review.Journal of thoracic disease · 2022Review
- Evolution of a novel technology for gastroesophageal reflux disease: a safety perspective of magnetic sphincter augmentation.Diseases of the esophagus : official journal of the International Society for Diseases of the Esophagus · 2021Article
- Complete endoscopic removal of an eroded magnetic sphincter augmentation device.VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy · 2021Article
- Mind the Gap: Current Treatment Alternatives for GERD Patients Failing Medical Treatment and Not Ready for a Fundoplication.Surgical laparoscopy, endoscopy & percutaneous techniques · 2020Review
- LINXWorld journal of clinical cases · 2020Article
- Magnetic Sphincter Augmentation and Postoperative Dysphagia: Characterization, Clinical Risk Factors, and Management.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2020Article
- Tailored modern GERD therapy - steps towards the development of an aid to guide personalized anti-reflux surgery.Scientific reports · 2019Article
- Endoscopic applications of magnets for the treatment of gastrointestinal diseases.World journal of gastrointestinal endoscopy · 2019Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gastroesophageal reflux disease (GERD) results from incompetency of the lower esophageal sphincter that allows the contents of the stomach to reflux into the esophagus, the airways, and the mouth. The disease affects about 10% of the western population and has a profound negative impact on quality of life. The majority of patients are successfully treated with proton-pump inhibitors, but up to 40% have incomplete relief of symptoms even after dose adjustment. The laparoscopic Nissen fundoplication represents the surgical gold standard, but is largely underused because of the level of technical difficulty and the prevalence of side effects. These factors have contributed to the propensity of patients to continue with medical therapy despite inadequate symptom control and complications of the disease. As a consequence, a significant 'therapy gap' in the treatment of GERD remains evident in current clinical practice. The LINX(®) Reflux Management System (Torax Medical, St. Paul, MN, USA) is designed to provide a permanent solution to GERD by augmenting the sphincter barrier with a standardized, reproducible laparoscopic procedure that does not alter gastric anatomy and is easily reversible. Two single-group trials confirmed that a magnetic device designed to augment the lower esophageal sphincter can be safely and effectively implanted using a standard laparoscopic approach. The device decreased esophageal acid exposure, improved reflux symptoms and quality of life, and allowed cessation of proton-pump inhibitors in the majority of patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.