ArticlePatient preference and adherence2013
Health-related quality of life in dialysis patients with constipation: a cross-sectional study.
Article in Patient preference and adherence, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04527640 (Effects of Synbiotics Supplementation on the Concentration of the Uremic Toxin Indoxyl Sulfate, Symptoms of Constipation, and Constipation-related Quality of Life in End-stage Renal Disease Patients Undergoing Hemodialysis), which is not on this map. Cited by 25 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Synbiotics Supplementation on the Concentration of the Uremic Toxin Indoxyl Sulfate, Symptoms of Constipation, and Constipation-related Quality of Life in End-stage Renal Disease Patients Undergoing Hemodialysis
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Pooled it
- Effect of external therapies of traditional Chinese medicine on constipation in patients with CRF: A meta-analysis.PloS one · 2023Pooled it
- Association between Financial Hardship and Symptom Burden in Patients Receiving Maintenance Dialysis: A Systematic Review.International journal of environmental research and public health · 2021Pooled it
- The effects of synbiotics on indoxyl sulphate level, constipation, and quality of life associated with constipation in chronic haemodialysis patients: a randomized controlled trial.BMC nephrology · 2022Trial
- Comparison of pregabalin with ondansetron in treatment of uraemic pruritus in dialysis patients: a prospective, randomized, double-blind study.International urology and nephrology · 2015Trial
- Effects of Fructo-Oligosaccharide Supplementation on Constipation in Elderly Continuous Ambulatory Peritoneal Dialysis Patients.Peritoneal dialysis international : journal of the International Society for Peritoneal DialysisTrial
- Tenapanor Beyond Phosphate: Gut Sodium Transport, Stool Transit Time, and Volume Balance in Dialysis Patients.Hemodialysis international. International Symposium on Home Hemodialysis · 2026Review
- Randomized Clinical Trial on the Efficacy and Safety of Preoperative Enema in the Prevention of Peritoneal Dialysis Catheter Dysfunction.Kidney international reports · 2026Article
- Evaluation of Constipation and Quality of Life Among Individuals Undergoing Hemodialysis: A Single-Center Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2025Article
- Gastrointestinal disease in end-stage renal disease.World journal of nephrology · 2025Review
- Constipation and risk of death and cardiovascular events in patients on hemodialysis.Kidney research and clinical practice · 2025Article
- Association between constipation and incident chronic kidney disease in the UK Biobank study.Scientific reports · 2024Article
- Article
- Real-world evidence of constipation and laxative use in the Korean population with chronic kidney disease from a common data model.Scientific reports · 2024Observational
- Gutted: constipation in children with chronic kidney disease and on dialysis.Pediatric nephrology (Berlin, Germany) · 2023Review
- Bowel habits were associated with mortality in chronic kidney disease: results from a nationwide prospective cohort study.Renal failure · 2023Article
- Patient-reported gastrointestinal symptoms in patients with peritoneal dialysis: the prevalence, influence factors and association with quality of life.BMC nephrology · 2022Article
- Gastrointestinal symptoms in HIV-positive kidney transplant candidates and recipients from an HIV-positive donor.Scientific reports · 2021Article
- Constipation in CKD.Kidney international reports · 2020Review
- Preliminary evaluation of fecal fatty acid concentrations in cats with chronic kidney disease and correlation with indoxyl sulfate and p-cresol sulfate.Journal of veterinary internal medicine · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo evaluate differences in the health-related quality of life (HRQoL) between patients with constipation receiving hemodialysis (HD) and those receiving peritoneal dialysis (PD).
methodsIn this cross-sectional study, 605 dialysis patients (478 HD cases and 127 PD cases; all patients were older than 18 years) from our hospital were included. A questionnaire was used to evaluate their constipation statuses. The effect of constipation on HRQoL was assessed, using the Chinese version of the 12-item short-form (SF-12) general health survey. Karnofsky score, sociodemographic, and clinical data were also collected. We performed multiple logistic regression analysis to define independent risk factors for constipation and impaired HRQoL.
resultsA total of 605 participants (326 men [53.9%] and 279 women [46.1%]) were surveyed. The incidence of constipation was 71.7% in HD patients and 14.2% in PD patients. Dialysis patients with constipation had significantly lower mean SF-12 Physical Component Summary scale and Mental Component Summary scale scores than the nonconstipation group (P < 0.05), whereas HD patients had better SF-12 Physical Component Summary and Mental Component Summary scores than PD patients (P < 0.05). When we performed multivariate logistic regression analysis, dialysis modality, diabetes, and the number of constipation-related medications were three independent risk factors associated with constipation. As for impaired HRQoL in the constipated dialysis population, dialysis modality was found to be another independent risk factor in addition to age and diabetes.
conclusionPD patients with constipation had worse HRQoL than HD control participants. We should pay more attention to the patients with constipation receiving PD, as peritonitis caused by constipation was associated with a higher mortality.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.