ArticleBMJ case reports2013
Growth of corneal epithelial cells over in situ therapeutic contact lens after simple limbal epithelial transplantation (SLET).
Article in BMJ case reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Clinical Outcomes of Different Surgical Techniques in Limbal Stem Cell Deficiency.Turkish journal of ophthalmology · 2025Article
- [Allogeneic simple limbal epithelial transplantation (alloSLET)-Treatment of bilateral limbal stem cell insufficiency].Die Ophthalmologie · 2023Article
- Innovative technique of mini-simple limbal epithelial transplantation in pediatric patients.Indian journal of ophthalmology · 2021Article
- Simple limbal epithelial transplantation: Current status and future perspectives.Stem cells translational medicine · 2020Review
- Limbal Stem Cell Deficiency: Current Treatment Options and Emerging Therapies.Stem cells international · 2016Review
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Authors and funding
3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
An 11-year-old boy underwent simple limbal epithelial transplantation (SLET) from the healthy right eye to his left eye for total limbal stem cell deficiency. One month later, corneal surface epithelialised and whitish plaques overlying the transplants were seen inferiorly. Those plaques were adherent to the surface of the contact lens and underlying corneal surface had smooth elevations. Similar findings were noted in a 23-year man following cyanoacrylate glue application for corneal perforation. On histological and immunohistochemical analysis, cells lining the contact lenses were identified as corneal epithelial cells. These cases illustrate epithelial cell growth on the contact lens and epithelial hyperplasia on corresponding surface of the cornea. Exorbitant proliferation of the epithelial cells may be owing to young age; therefore, early contact lens removal after SLET in young age, can possibly avoid epithelial hyperplasia. This also reiterates the possibility of using contact lens as a scaffold to grow epithelial cells.
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