ArticleHuman molecular genetics2013
Modularization and epistatic hierarchy determine homeostatic actions of multiple blood pressure quantitative trait loci.
Article in Human molecular genetics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 32 citations in OpenAlex.
- Modularized Genes in an Adrenal Pathway Reveal a Novel Mechanism in Hypertension Pathogenesis.International journal of molecular sciences · 2025Article
- Shifting Paradigm from Gene Expressions to Pathways Reveals Physiological Mechanisms in Blood Pressure Control in Causation.International journal of molecular sciences · 2023Article
- Genetics of Normotension Preventing Hypertension Leads to a Novel Physiological Paradigm.Reviews in cardiovascular medicine · 2022Review
- Hypothalamic Norepinephrine Concentration and Heart Mass in Hypertensive ISIAH Rats Are Associated with a Genetic Locus on Chromosome 18.Journal of personalized medicine · 2021Article
- Modularity/non-cumulativity of quantitative trait loci on blood pressure.Journal of human hypertension · 2020Review
- Conserved mammalian modularity of quantitative trait loci revealed human functional orthologs in blood pressure control.PloS one · 2020Article
- Will the real Dahl S rat please stand up?American journal of physiology. Renal physiology · 2019Article
- A unified mapping framework of multifaceted pharmacodynamic responses to hypertension interventions.Drug discovery today · 2019Review
- Chrm3 Gene and M3 Muscarinic Receptors Contribute to Salt-Sensitive Hypertension.Hypertension (Dallas, Tex. : 1979) · 2018Article
- Towards Precision Medicine for Hypertension: A Review of Genomic, Epigenomic, and Microbiomic Effects on Blood Pressure in Experimental Rat Models and Humans.Physiological reviews · 2017Review
- Contribution of independent and pleiotropic genetic effects in the metabolic syndrome in a hypertensive rat.PloS one · 2017Article
- Alterations in Fibronectin Type III Domain Containing 1 Protein Gene Are Associated with Hypertension.PloS one · 2016Article
- Isolation of a Genomic Region Affecting Most Components of Metabolic Syndrome in a Chromosome-16 Congenic Rat Model.PloS one · 2016Article
- Dr Lewis Kitchener Dahl, the Dahl rats, and the "inconvenient truth" about the genetics of hypertension.Hypertension (Dallas, Tex. : 1979) · 2015Article
- PhenoMiner: a quantitative phenotype database for the laboratory rat, Rattus norvegicus. Application in hypertension and renal disease.Database : the journal of biological databases and curation · 2015Article
- Do epistatic modules exist in the genetic control of blood pressure in Dahl rats? A critical perspective.Physiological genomics · 2013Article
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5 authors at 1 institution in 1 country.
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Abstract
Hypertension, the most frequently diagnosed clinical condition world-wide, predisposes individuals to morbidity and mortality, yet its underlying pathological etiologies are poorly understood. So far, a large number of quantitative trait loci (QTLs) have been identified in both humans and animal models, but how they function together in determining overall blood pressure (BP) in physiological settings is unknown. Here, we systematically and comprehensively performed pair-wise comparisons of individual QTLs to create a global picture of their functionality in an inbred rat model. Rather than each of numerous QTLs contributing to infinitesimal BP increments, a modularized pattern arises: two epistatic 'blocks' constitute basic functional 'units' for nearly all QTLs, designated as epistatic module 1 (EM1) and EM2. This modularization dictates the magnitude and scope of BP effects. Any EM1 member can contribute to BP additively to that of EM2, but not to those of the same module. Members of each EM display epistatic hierarchy, which seems to reflect a related functional pathway. Rat homologues of 11 human BP QTLs belong to either EM1 or EM2. Unique insights emerge into the novel genetic mechanism and hierarchy determining BP in the Dahl salt-sensitive SS/Jr (DSS) rat model that implicate a portion of human QTLs. Elucidating the pathways underlying EM1 and EM2 may reveal the genetic regulation of BP.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.