ArticleJournal of applied physiology (Bethesda, Md. : 1985)2013
Mitochondrial function and increased convective O2 transport: implications for the assessment of mitochondrial respiration in vivo.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Pooled it
- Exercising calf muscle T₂∗ changes correlate with pH, PCr recovery and maximum oxidative phosphorylation.NMR in biomedicine · 2014Trial
- Neither intracellular oxygen availability nor mitochondrial coupling explain lower oxidative capacity in older human vastus lateralis muscle in vivo.The Journal of physiology · 2026Article
- Correction of hypoxemia and hypoglycemia restores muscle mitochondrial respiration and remodels mitochondrial proteome in growth-restricted sheep fetuses.American journal of physiology. Endocrinology and metabolism · 2026Article
- Correlates of exercise hyperemia and muscle energetics in the human upper arm.bioRxiv : the preprint server for biology · 2025Article
- Limb, sex, but not acute dietary capsaicin, modulate the near-infrared spectroscopy-vascular occlusion test estimate of muscle metabolism.Physiological reports · 2024Article
- A systematic review of the relationship between muscle oxygen dynamics and energy rich phosphates. Can NIRS help?BMC sports science, medicine & rehabilitation · 2024Article
- Microcirculation and Mitochondria: The Critical Unit.Journal of clinical medicine · 2023Review
- The role of the microcirculation and integrative cardiovascular physiology in the pathogenesis of ICU-acquired weakness.Frontiers in physiology · 2023Review
- Article
- Microcirculation dysfunction in endotoxic shock rabbits is associated with impaired S-nitrosohemoglobin-mediated nitric oxide release from red blood cells: a preliminary study.Intensive care medicine experimental · 2019Article
- Oxygen availability and skeletal muscle oxidative capacity in patients with peripheral artery disease: implications from in vivo and in vitro assessments.American journal of physiology. Heart and circulatory physiology · 2018Article
- Modification of a three-compartment muscle fatigue model to predict peak torque decline during intermittent tasks.Journal of biomechanics · 2018Article
- Influence of group III/IV muscle afferents on small muscle mass exercise performance: a bioenergetics perspective.The Journal of physiology · 2018Article
- Bioenergetics and ATP Synthesis during Exercise: Role of Group III/IV Muscle Afferents.Medicine and science in sports and exercise · 2017Article
- Oxygen delivery and the restoration of the muscle energetic balance following exercise: implications for delayed muscle recovery in patients with COPD.American journal of physiology. Endocrinology and metabolism · 2017Article
- Article
- Accuracy and precision of quantitative 31P-MRS measurements of human skeletal muscle mitochondrial function.American journal of physiology. Endocrinology and metabolism · 2016Article
- Evidence of Preserved Oxidative Capacity and Oxygen Delivery in the Plantar Flexor Muscles With Age.The journals of gerontology. Series A, Biological sciences and medical sciences · 2015Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Although phosphorus magnetic resonance spectroscopy (31P-MRS)-based evidence suggests that in vivo peak mitochondrial respiration rate in young untrained adults is limited by the intrinsic mitochondrial capacity of ATP synthesis, it remains unknown whether a large, locally targeted increase in convective O2 delivery would alter this interpretation. Consequently, we examined the effect of superimposing reactive hyperemia (RH), induced by a period of brief ischemia during the last minute of exercise, on oxygen delivery and mitochondrial function in the calf muscle of nine young adults compared with free-flow conditions (FF). To this aim, we used an integrative experimental approach combining 31P-MRS, Doppler ultrasound imaging, and near-infrared spectroscopy. Limb blood flow [area under the curve (AUC), 1.4 ± 0.8 liters in FF and 2.5 ± 0.3 liters in RH, P < 0.01] and convective O2 delivery (AUC, 0.30 ± 0.16 liters in FF and 0.54 ± 0.05 liters in RH, P < 0.01), were significantly increased in RH compared with FF. RH was also associated with significantly higher capillary blood flow (P < 0.05) and faster tissue reoxygenation mean response times (70 ± 15 s in FF and 24 ± 15 s in RH, P < 0.05). This resulted in a 43% increase in estimated peak mitochondrial ATP synthesis rate (29 ± 13 mM/min in FF and 41 ± 14 mM/min in RH, P < 0.05) whereas the phosphocreatine (PCr) recovery time constant in RH was not significantly different (P = 0.22). This comprehensive assessment of local skeletal muscle O2 availability and utilization in untrained subjects reveals that mitochondrial function, assessed in vivo by 31P-MRS, is limited by convective O2 delivery rather than an intrinsic mitochondrial limitation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.