ArticleMolecular and cellular biochemistry2013
Tumor necrosis factor-α-mediated suppression of dual-specificity phosphatase 4: crosstalk between NFκB and MAPK regulates endothelial cell survival.
Article in Molecular and cellular biochemistry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 14 citations in OpenAlex.
- Th17-Derived Cytokines Synergistically Enhance IL-17C Production by the Colonic Epithelium.Journal of immunology (Baltimore, Md. : 1950) · 2022Article
- 11,12 Epoxyeicosatrienoic Acid Rescues Deteriorated Wound Healing in Diabetes.International journal of molecular sciences · 2021Article
- Immunometabolic Endothelial Phenotypes: Integrating Inflammation and Glucose Metabolism.Circulation research · 2021Article
- Aberrant expression of DUSP4 is a specific phenomenon in betel quid-related oral cancer.Medical molecular morphology · 2021Article
- Oral Selumetinib Does Not Negatively Impact Photoreceptor Survival in Murine Experimental Retinal Detachment.Investigative ophthalmology & visual science · 2019Article
- EphA2 stimulates VCAM-1 expression through calcium-dependent NFAT1 activity.Cellular signalling · 2018Article
- Novel Mechanisms Modulating Palmitate-Induced Inflammatory Factors in Hypertrophied 3T3-L1 Adipocytes by AMPK.Journal of diabetes research · 2018Article
- Dual-Specificity Phosphatase 4 Overexpression in Cells Prevents Hypoxia/Reoxygenation-Induced ApoptosisFrontiers in cardiovascular medicine · 2017Article
- Suberoylanilide Hydroxamic Acid, an Inhibitor of Histone Deacetylase, Induces Apoptosis in Rheumatoid Arthritis Fibroblast-Like Synoviocytes.Inflammation · 2016Article
- Modulation of p38 kinase by DUSP4 is important in regulating cardiovascular function under oxidative stress.Free radical biology & medicine · 2015Article
- Molecular characterization of the peripheral airway field of cancerization in lung adenocarcinoma.PloS one · 2015Article
- Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
We investigated the effects of tumor necrosis factor-α (TNF-α) exposure on mitogen-activated protein kinase signaling in human microvascular endothelial cells. TNF-α caused a significant suppression of a dual specificity phosphatase, DUSP4, that regulates ERK1/2 activation. Thus, we hypothesized that suppression of DUSP4 enhances cell survival by increasing ERK1/2 signaling in response to growth factor stimulation. In support of this concept, TNF-α pre-exposure increased growth factor-mediated ERK1/2 activation, whereas overexpression of DUSP4 with an adenovirus decreased ERK1/2 compared to an empty adenovirus control. Overexpression of DUSP4 also significantly decreased cell viability, lessened recovery in an in vitro wound healing assay, and decreased DNA synthesis. Pharmacological inhibition of NFκB activation or a dominant negative construct of the inhibitor of κB significantly lessened TNF-α-mediated suppression of DUSP4 expression by 70-84% and attenuated ERK activation, implicating NFκB-dependent pathways in the TNF-α-mediated suppression of DUSP4 that contributes to ERK1/2 signaling. Taken together, our findings show that DUSP4 attenuates ERK signaling and reduces cell viability, suggesting that the novel crosstalk between NFκB and MAPK pathways contributes to cell survival.
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