Trial reportPsychopharmacology2013
Effects of acute alcohol intoxication on saccadic conflict and error processing.
Trial report in Psychopharmacology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed.
- An interoceptive basis for alcohol priming effects.Psychopharmacology · 2021Trial
- Dose-dependent effects of intravenous alcohol administration on cerebral blood flow in young adults.Psychopharmacology · 2015Trial
- Moderating effect of working memory capacity on acute alcohol effects on BOLD response during inhibition and error monitoring in male heavy drinkers.Psychopharmacology · 2015Trial
- Sex differences in neural circuits driving binge-like drinking: a female-specific role for an amygdalo-striatal pathway.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- The eyes have it: Alcohol-induced eye movement impairment and perceived impairment in older adults with and without alcohol use disorder.Alcohol, clinical & experimental research · 2025Article
- A narrative review on alcohol use in women: insight into the telescoping hypothesis from a biopsychosocial perspective.The American journal of drug and alcohol abuse · 2025Review
- Theta oscillatory dynamics of inhibitory control, error processing, and post-error adjustments: Neural underpinnings and alcohol-induced dysregulation in social drinkers.Alcoholism, clinical and experimental research · 2022Article
- Sex/gender differences in brain function and structure in alcohol use: A narrative review of neuroimaging findings over the last 10 years.Journal of neuroscience research · 2021Review
- Sex Differences in Substance Use Disorders: A Neurobiological Perspective.Frontiers in global women's health · 2021Review
- Binge drinking is associated with altered resting state functional connectivity of reward-salience and top down control networks.Brain imaging and behavior · 2020Article
- Chronic Alcohol Exposure Induces Aberrant Mitochondrial Morphology and Inhibits Respiratory Capacity in the Medial Prefrontal Cortex of Mice.Frontiers in neuroscience · 2020Article
- Neural oscillatory dynamics of inhibitory control in young adult binge drinkers.Biological psychology · 2019Article
- Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication.Journal of visualized experiments : JoVE · 2019Article
- Alcohol effects on response inhibition: Variability across tasks and individuals.Experimental and clinical psychopharmacology · 2018Article
- Behavioral and Brain Activity Indices of Cognitive Control Deficits in Binge Drinkers.Brain sciences · 2018Article
- Article
- Effects of acute alcohol ingestion on eye movements and cognition: A double-blind, placebo-controlled study.PloS one · 2017Article
- Alcohol Hits You When It Is Hard: Intoxication, Task Difficulty, and Theta Brain Oscillations.Alcoholism, clinical and experimental research · 2016Article
- Spatio-temporal processing of words and nonwords: hemispheric laterality and acute alcohol intoxication.Brain research · 2014Article
- Alcohol and the Eye.Journal of ophthalmic & vision researchReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
rationaleFlexible behavior optimization relies on cognitive control which includes the ability to suppress automatic responses interfering with relevant goals. Extensive evidence suggests that the anterior cingulate cortex (ACC) is the central node in a predominantly frontal cortical network subserving executive tasks. Neuroimaging studies indicate that the ACC is sensitive to acute intoxication during conflict, but such evidence is limited to tasks using manual responses with arbitrary response contingencies.
objectivesThe present study was designed to examine whether alcohol's effects on top-down cognitive control would generalize to the oculomotor system during inhibition of hardwired saccadic responses.
methodsHealthy social drinkers (N = 22) underwent functional magnetic resonance imaging (fMRI) scanning and eye movement tracking during alcohol (0.6 g/kg ethanol for men, 0.55 g/kg for women) and placebo conditions in a counterbalanced design. They performed visually guided prosaccades (PS) towards a target and volitional antisaccades (AS) away from it. To mitigate possible vasoactive effects of alcohol on the BOLD (blood oxygenation level-dependent) signal, resting perfusion was quantified with arterial spin labeling (ASL) and used as a covariate in the BOLD analysis.
resultsSaccadic conflict was subserved by a distributed frontoparietal network. However, alcohol intoxication selectively attenuated activity only in the ACC to volitional AS and erroneous responses.
conclusionsThis study provides converging evidence for the selective ACC vulnerability to alcohol intoxication during conflict across different response modalities and executive tasks, confirming its supramodal, high-level role in cognitive control. Alcohol intoxication may impair top-down regulative functions by attenuating the ACC activity, resulting in behavioral disinhibition and decreased self-control.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.