ArticleProceedings of the National Academy of Sciences of the United States of America2013
Signaling through hepatocellular A2B adenosine receptors dampens ischemia and reperfusion injury of the liver.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 34 citations in OpenAlex.
- Sevoflurane Dampens Acute Pulmonary Inflammation via the Adenosine Receptor A2B and Heme Oxygenase-1.Cells · 2022Article
- Hypoxia-inducible factor-1alpha protects the liver against ischemia-reperfusion injury by regulating the A2B adenosine receptor.Bioengineered · 2021Article
- Switching-Off Adora2b in Vascular Smooth Muscle Cells Halts the Development of Pulmonary Hypertension.Frontiers in physiology · 2018Article
- An Evaluation of Ischaemic Preconditioning as a Method of Reducing Ischaemia Reperfusion Injury in Liver Surgery and Transplantation.Journal of clinical medicine · 2017Review
- Lung injury pathways: Adenosine receptor 2B signaling limits development of ischemic bronchiolitis obliterans organizing pneumonia.Experimental lung research · 2017Article
- Innate Immune Regulations and Liver Ischemia-Reperfusion Injury.Transplantation · 2016Review
- Upregulation of P2Y2 nucleotide receptor in human hepatocellular carcinoma cells.The Journal of international medical research · 2016Article
- Neurologic cues modulate immune-mediated liver injury and regeneration.Hepatology (Baltimore, Md.) · 2016Article
- Abate Cytochrome C induced apoptosome to protect donor liver against ischemia reperfusion injury on rat liver transplantation model.American journal of translational research · 2016Article
- I drink for my liver, Doc: emerging evidence that coffee prevents cirrhosis.F1000Research · 2015Review
- Article
- Deletion of ADORA2B from myeloid cells dampens lung fibrosis and pulmonary hypertension.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- MMP-9 deficiency shelters endothelial PECAM-1 expression and enhances regeneration of steatotic livers after ischemia and reperfusion injury.Journal of hepatology · 2014Article
- N-acetyl-serotonin protects HepG2 cells from oxidative stress injury induced by hydrogen peroxide.Oxidative medicine and cellular longevity · 2014Article
- Transplantation: ADORA2B helps to block liver injury.Nature reviews. Gastroenterology & hepatology · 2013Article
Corrections and comments
- Retraction · 2017-06-19Duplication of/in Image · Investigation by Company/Institution · · Almut Gren has a institutional finding of misconduct (not in regards to this paper) : http://retractionwatch.com/wp-content/uploads/2017/06/Investigative-Report_1.pdf
- Commented on by
- Retracted
Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
Abstract
Ischemia and reperfusion significantly contributes to the morbidity and mortality of liver surgery and transplantation. Based on studies showing a critical role for adenosine signaling in mediating tissue adaptation during hypoxia, we hypothesized that signaling events through adenosine receptors (ADORA1, ADORA2A, ADORA2B, or ADORA3) attenuates hepatic ischemia and reperfusion injury. Initial screening studies of human liver biopsies obtained during hepatic transplantation demonstrated a selective and robust induction of ADORA2B transcript and protein following ischemia and reperfusion. Subsequent exposure of gene-targeted mice for each individual adenosine receptor to liver ischemia and reperfusion revealed a selective role for the Adora2b in liver protection. Moreover, treatment of wild-type mice with an Adora2b-selective antagonist resulted in enhanced liver injury, whereas Adora2b-agonist treatment was associated with attenuated hepatic injury in wild-type, but not in Adora2b(-/-) mice. Subsequent studies in mice with Adora2b deletion in different tissues--including vascular endothelia, myeloid cells, and hepatocytes--revealed a surprising role for hepatocellular-specific Adora2b signaling in attenuating nuclear factor NF-κB activation and thereby mediating liver protection from ischemia and reperfusion injury. These studies provide a unique role for hepatocellular-specific Adora2b signaling in liver protection during ischemia and reperfusion injury.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.