ArticleObstetrics and gynecology2013
Relationship between 1-hour glucose challenge test results and perinatal outcomes.
Article in Obstetrics and gynecology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00069576 (A Randomized Clinical Trial of Treatment for Mild Gestational Diabetes Mellitus), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Randomized Clinical Trial of Treatment for Mild Gestational Diabetes Mellitus
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Hyperglycaemia and risk of adverse perinatal outcomes: systematic review and meta-analysis.BMJ (Clinical research ed.) · 2016 · on this mapPooled it
- Article
- Does the gestational age at which the glucose challenge test (GCT) is conducted influence the diagnosis of gestational diabetes mellitus (GDM)?Archives of gynecology and obstetrics · 2024Article
- Pregnancy phthalate metabolite concentrations and infant birth weight by gradations of maternal glucose tolerance.International journal of hygiene and environmental health · 2019Article
- Predictive Characteristics of Elevated 1-Hour Glucose Challenge Test Results for Gestational Diabetes.American journal of perinatology · 2017Article
- Observational
- Maternal Glucose and Fatty Acid Kinetics and Infant Birth Weight in Obese Women With Type 2 Diabetes.Diabetes · 2016Article
- Pregnancy Outcomes in Women with 1-Hour Glucose Challenge Test ≥ 200 mg/dL.American journal of perinatology · 2016Article
- Prevalence of Adverse Pregnancy Outcomes, by Maternal Diabetes Status at First and Second Deliveries, Massachusetts, 1998-2007.Preventing chronic disease · 2015Article
- A mother's influence on metabolic disorders.Nature medicine · 2014Article
Corrections and comments
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Authors and funding
18 authors.
Funding
Abstract
objectiveTo estimate the relationship between 1-hour 50 g glucose challenge test values and perinatal outcomes.
methodsThis was a secondary analysis of data from a multicenter treatment trial of mild gestational diabetes mellitus. Women with glucose challenge test values of 135-199 mg/dL completed a 3-hour oral glucose tolerance test. Mild gestational diabetes mellitus was defined as fasting glucose less than 95 mg/dL and two or more abnormal oral glucose tolerance test values: 1-hour 180 mg/dL or more; 2-hour 155 mg/dL or more; and 3-hour 140 mg/dL or more. Our study included untreated women with glucose challenge test values of 135-139 mg/dL and 140-199 mg/dL and a comparison group with values less than 120 mg/dL. Primary outcomes included a perinatal composite (stillbirth, neonatal death, hypoglycemia, hyperbilirubinemia, neonatal hyperinsulinemia, and birth trauma), large for gestational age (LGA, birth weight above the 90 percentile based on sex-specific and race-specific norms), and macrosomia (greater than 4,000 g).
resultsThere were 436 women with glucose challenge test values less than 120 mg/dL and 1,403 with values of 135 mg/dL or more (135-139, n=135; 140-199, n=1,268). The composite perinatal outcome occurred in 25.6% of those with glucose challenge test values less than 120 mg/dL compared with 21.1% for values of 135-139 mg/dL and 35.3% for values of 140-199 mg/dL. Rates of LGA by group were 6.6%, 6.8%, and 12.4%, respectively. Rates of macrosomia by group were 7.8%, 6.1%, and 12.1%, respectively. Compared with glucose challenge test values less than 120 mg/dL, the adjusted odds ratios (ORs) (95% confidence intervals [CIs]) for values of 140-199 mg/dL were 1.48 (1.14-1.93) for the composite outcome, 1.97 (1.29-3.11) for LGA, and 1.61 (1.07-2.49) for macrosomia. For glucose challenge test values of 135-139 mg/dL, adjusted ORs and 95% CIs were 0.75 (0.45-1.21), 1.04 (0.44-2.24), and 0.75 (0.30-1.66), respectively. The subcategories with glucose challenge test values of 140-144 mg/dL and 145-149 mg/dL also were associated with an increase in selected outcomes when compared with those with values less than 120 mg/dL.
conclusionsGlucose challenge test values of 135-139 mg/dL were not associated with adverse outcomes compared with values less than 120 mg/dL; however, glucose challenge test values of 140 mg/dL or more were associated with an increase in odds of the composite perinatal outcome, LGA, and macrosomia.
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